n',n'-Diphenylacetohydrazide

Base Information

• Chemical Name: n',n'-Diphenylacetohydrazide
• CAS No.: 6233-05-2
• Molecular Formula: C14H14 N2 O
• Molecular Weight: 226.278
• NSC Number: 45052
• DSSTox Substance ID: DTXSID80977882
• Nikkaji Number: J3.409.236B
• Wikidata: Q82963187
• Mol file: 6233-05-2.mol

Synonyms:n',n'-diphenylacetohydrazide;6233-05-2;N-Acetyl-1,1-diphenylhydrazine;NSC45052;Acetylamino-diphenylamin;starbld0049342;Oprea1_104399;Oprea1_164255;SCHEMBL12305493;DTXSID80977882;N,N-Diphenylethanehydrazonic acid;NSC-45052;AKOS008542382

Chemical Property of n',n'-Diphenylacetohydrazide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.151g/cm³
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 226.110613074
• Heavy Atom Count: 17
• Complexity: 225

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NN(C1=CC=CC=C1)C2=CC=CC=C2

Technology Process of n',n'-Diphenylacetohydrazide

There total 7 articles about n',n'-Diphenylacetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-acetyl-2-phenylhydrazine (114-83-0) → 2-acetyl-1,1-diphenylhydrazine (6233-05-2)

Guidance literature:

With 1,10-Phenanthroline; copper(II) acetate monohydrate; triethylamine; In methanol; at 20 ℃; regioselective reaction;

DOI:10.1039/c4ob02343a

Reference yield: 69.0%

3-methyl-5H-1,4,2-dioxazol-5-one + diphenylamine (122-39-4) → 2-acetyl-1,1-diphenylhydrazine (6233-05-2)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; In chloroform; at 25 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1038/s41557-021-00650-0

Reference yield: 49.0%

acetic anhydride (108-24-7) + 1,1-Diphenylhydrazine (530-50-7) → 2-acetyl-1,1-diphenylhydrazine (6233-05-2)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; for 1h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c4cc01520g

upstream raw materials:

acetic anhydride

1,1-Diphenylhydrazine

acetyl chloride

1-acetyl-2-phenylhydrazine

Downstream raw materials:

ethyl 2-(2-acetyl-1-phenyl-2,3-dihydro-1H-indazol-3-yl)acetate

2,3-diacetyl-1,1,4,4-tetraphenyl-tetrazane

Refernces

• 1、 Wang, Hao,Jung, Hoimin,Song, Fangfang,Zhu, Shiyang,Bai, Ziqian,Chen, Danye,He, Gang,Chang, Sukbok,Chen, Gong. "Nitrene-mediated intermolecular N–N coupling for efficient synthesis of hydrazides". . p. 378 - 385. Retrieved 2021/03/31.
• 2、 Liang, Yujie,Yu, Ke,Li, Bin,Xu, Shansheng,Song, Haibin,Wang, Baiquan. "Rh(iii)-catalyzed synthesis of 1-aminoindole derivatives from 2-acetyl-1-arylhydrazines and diazo compounds in water". supporting information. p. 6130 - 6133. Retrieved 2014/06/09.