114-83-0

Basic information

• Product Name: 1-Acetyl-2-phenylhydrazine
• Synonyms: 1-Acetyl-2-phenylhydrazine,98%;1-Acetyl-2-phenylhyd;1-Acetyl-2-Phenyl Hydrazine (APH);N-Acetyl-N'-phenylhydrazine, 98%, 98%;N-Acetylphenylhydrazine N-Acetylphenyl hydrazine 2-Phenylacetohydrazide;2-Phenylacetohydrazide for synthesis;N'-PHENYLACETOHYDRAZIDE;N-ACETYLHYDRAZINOBENZENE
• CAS NO: 114-83-0
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.18
• EINECS: 204-055-3
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes;Phenylhydrazine;Cancer Research;Carcinogens
• Mol File: 114-83-0.mol
• Article Data: 34

Chemical Properties

• Melting Point: 128-131 °C(lit.)
• Boiling Point: 271.72°C (rough estimate)
• Flash Point: 87.8 °C
• Appearance: colorless prisms or white solid
• Density: 1.1392 (rough estimate)
• Vapor Pressure: 1E-06mmHg at 25°C
• Refractive Index: 1.6180 (estimate)
• Storage Temp.: Store at +15°C to +25°C.
• Solubility: soluble in Alcohol
• PKA: 12.75±0.23(Predicted)
• Water Solubility: <0.1 g/100 mL at 19 C
• BRN: 742880
• CAS DataBase Reference: 1-Acetyl-2-phenylhydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Acetyl-2-phenylhydrazine(114-83-0)
• EPA Substance Registry System: 1-Acetyl-2-phenylhydrazine(114-83-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38-43-20/21/22
• Safety Statements: 22-26-36-24/25-36/37
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: AJ2900000
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 114-83-0(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powde

Uses

1-Acetyl-2-phenylhydrazine is an Anaerobically curable compound.

Synthesis Reference(s)

The Journal of Organic Chemistry, 30, p. 2486, 1965 DOI: 10.1021/jo01018a525

General Description

Colorless prisms or white solid.

Air & Water Reactions

Water insoluble.

Reactivity Profile

1-Acetyl-2-phenylhydrazine is an amide and an amine. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition 1-Acetyl-2-phenylhydrazine emits toxic fumes.

Fire Hazard

Flash point data for 1-Acetyl-2-phenylhydrazine are not available. 1-Acetyl-2-phenylhydrazine is probably combustible.

Purification Methods

Crystallise the hydrazine from aqueous EtOH. [Beilstein 15 H 241.]

InChI:InChI=1/C6H8N2.C2H4O2/c7-8-6-4-2-1-3-5-6;1-2(3)4/h1-5,8H,7H2;1H3,(H,3,4)

Synthetic route

acetic anhydride (108-24-7) + phenylhydrazine (100-63-0) → 1-acetyl-2-phenylhydrazine (114-83-0)

Conditions	Yield
In diethyl ether at 0℃; for 10h;	100%
Stage #1: phenylhydrazine With triethylamine In dichloromethane at 0℃; Inert atmosphere; Stage #2: acetic anhydride In dichloromethane at 0 - 20℃; Inert atmosphere;	97%
With pyridine; aluminum oxide at 90 - 92℃; for 1h; microwave irradiation;	65%

1,1,1-trichloroacetone (918-00-3) + phenylhydrazine (100-63-0) → 1-acetyl-2-phenylhydrazine (114-83-0)

Conditions	Yield
With triethylamine In acetonitrile for 8h; Heating;	98%

acetic acid (64-19-7) + phenylhydrazine (100-63-0) → 1-acetyl-2-phenylhydrazine (114-83-0)

Conditions	Yield
at 80℃; for 3.5h; Inert atmosphere;	96%
at 80℃; for 1.5h;	85%
at 20 - 80℃; for 1.5h; Inert atmosphere;	81%

4-Acetamido-1-iodobenzene (622-50-4) + phenylhydrazine (100-63-0) → 1-acetyl-2-phenylhydrazine (114-83-0)

Conditions	Yield
at 95℃; for 2.5h; Temperature;	93%

phenylhydrazine (100-63-0) + thioacetic acid (507-09-5) → 1-acetyl-2-phenylhydrazine (114-83-0)

Conditions	Yield
With copper(II)-grafted guanidine acetic acid-modified magnetite nanoparticles In water at 20℃; for 0.0833333h; Green chemistry; chemoselective reaction;	90%
With Fe3O4(at)Chit-TCT-Salen-Cu(II) In water at 20℃; for 0.0833333h; regioselective reaction;	89%

phenylhydrazine hydrochloride (59-88-1) + acetic acid (64-19-7) → 1-acetyl-2-phenylhydrazine (114-83-0)

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	89%

phenylhydrazine hydrochloride (59-88-1) + acetic anhydride (108-24-7) → 1-acetyl-2-phenylhydrazine (114-83-0)

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 24h;	87%
With potassium carbonate In ethyl acetate at 20℃; for 7h; Inert atmosphere; regioselective reaction;	82%
With sodium hydroxide In tetrahydrofuran for 0.5h; Inert atmosphere;
With sodium hydroxide In tetrahydrofuran for 0.5h;

phenylhydrazine (100-63-0) + acetone (67-64-1) → 1-acetyl-2-phenylhydrazine (114-83-0)

Conditions	Yield
With chloroform; dimethyl sulfoxide at 120℃; for 24h; Green chemistry;	84%

acetamide (60-35-5) + phenylhydrazine (100-63-0) → 1-acetyl-2-phenylhydrazine (114-83-0)

Conditions	Yield
With [bis(acetoxy)iodo]benzene In neat (no solvent) at 120℃; for 0.333333h; Microwave irradiation; Green chemistry;	83%
In 1,4-dioxane at 20℃; for 0.5h; Microwave irradiation; Sealed tube;	78%
With [Mn((N'1E,N'2E)-N'1,N'2-bis(phenyl(pyridin-2-yl)methylene)oxalohydrazide(-H))(OAc)(H2O)]2*6H2O In neat (no solvent) at 120℃; for 24h;	70%
at 160℃; under 12929 Torr; for 0.166667h; Microwave irradiation; Sealed tube;	54%
at 150℃;

benzenediazonium (2684-02-8) + dimethylglyoxal (431-03-8) → biacetyl phenylhydrazone (13732-32-6) + 1-acetyl-2-phenylhydrazine (114-83-0)

Conditions	Yield
With titanium(III) chloride In acetic acid for 0.666667h; Ambient temperature;	A 16% B 65%

mono-O-acetyl maleic hydrazide (15456-83-4) + phenylhydrazine (100-63-0) → 1-acetyl-2-phenylhydrazine (114-83-0)

Conditions	Yield
In N,N-dimethyl-formamide at 70 - 80℃; for 2h;	65%

phenylhydrazine (100-63-0) + ethyl 2-acetylacetoacetate (603-69-0) → 3-methyl-2-pyrazoline-5-one (108-26-9) + 1-acetyl-2-phenylhydrazine (114-83-0)

Conditions	Yield
In diethyl ether at -30 - -25℃;	A n/a B 64%

2,5-dimethyl-2-phenylazo-furan-3-one (70638-40-3) → Acetic acid N-((Z)-3-amino-but-2-enoyl)-N'-phenyl-hydrazide (83326-39-0) + 1-acetyl-2-phenylhydrazine (114-83-0)

Conditions	Yield
With ammonia In methanol 1.) 0 deg C, 15 min, 2.) RT; Yield given;	A 60% B n/a
With ammonia In methanol 1.) 0 deg C, 15 min, 2.) RT; Yields of byproduct given;	A 60% B n/a

benzene-1,2-diol (120-80-9) + 2-(diethylamino)-5-methyl-3-phenyl-2-(phenylimino)-Δ4-1,3,4,2λ5-oxadiazaphospholine (99049-24-8) → diethylammonium tris(o-phenylenedioxy)phosphate + 1-acetyl-2-phenylhydrazine (114-83-0)

Conditions	Yield
In chloroform for 0.5h; Heating;	A 53% B n/a

benzene-1,2-diol (120-80-9) + N-cyclohexyl-N'-phenylphosphorodiamidic 2-acetyl-1-phenylhydrazide (99049-28-2) → cyclohexylammonium tris(o-phenylenedioxy)phosphate + 1-acetyl-2-phenylhydrazine (114-83-0)

Conditions	Yield
In chloroform for 0.5h; Heating;	A 41% B n/a

benzenediazonium (2684-02-8) + 1-Phenylpropane-1,2-dione (579-07-7) → 1-phenyl-propane-1,2-dione-2-phenylhydrazone (20999-77-3) + 1-acetyl-2-phenylhydrazine (114-83-0) + N-benzoyl-N'-phenylhydrazine (532-96-7)

Conditions	Yield
With titanium(III) chloride In acetic acid at 50℃; for 0.666667h;	A 29% B 25% C 40%

phenylhydrazine (100-63-0) + 4-acetyl-3-amino-5-oxo-3-hexenenitrile (106823-51-2) → 1-acetyl-2-phenylhydrazine (114-83-0) + (Z)-3-Amino-5-oxo-hex-3-enenitrile + 5-cyanomethylene-3-methyl-1-phenylpyrazole

Conditions	Yield
In ethanol for 72h; Ambient temperature;	A 40% B 24% C 18%

benzenediazonium (2684-02-8) + 1-Phenylpropane-1,2-dione (579-07-7) → 1-phenyl-propane-1,2-dione-2-phenylhydrazone (20999-77-3) + 1-acetyl-1-benzoyl-2-phenylhydrazine (136953-46-3) + 1-acetyl-2-phenylhydrazine (114-83-0) + N-benzoyl-N'-phenylhydrazine (532-96-7)

Conditions	Yield
With titanium(III) chloride In acetic acid for 0.666667h;	A 28% B 35% C 10% D 22%

acetyl-methyl-malonic acid diethyl ester (28286-72-8) + phenylhydrazine acetate (72358-76-0) → 1-acetyl-2-phenylhydrazine (114-83-0)

(1-nitro-ethylidene)-phenyl-hydrazine (20604-81-3) → 1-acetyl-2-phenylhydrazine (114-83-0)

Conditions	Yield
With sodium methylate

N'-acetyl-N-formyl-N-phenylhydrazine → 1-acetyl-2-phenylhydrazine (114-83-0)

Conditions	Yield
With sodium carbonate

acetic anhydride (108-24-7) + acetone phenylhydrazone (103-02-6) → 1-acetyl-2-phenylhydrazine (114-83-0)

Conditions	Yield
With acetone

acetic anhydride (108-24-7) + acetone phenylhydrazone (103-02-6) → N'-acetyl-N'-phenylacetohydrazide (38604-74-9) + 1-acetyl-2-phenylhydrazine (114-83-0)

phenyl-hydrazine; sodium-compound (59105-56-5) + acetic anhydride (108-24-7) → 1-acetyl-2-phenylhydrazine (114-83-0)

diethyl ether (60-29-7) + acetic anhydride (108-24-7) + phenylhydrazine (100-63-0) → 1-acetyl-2-phenylhydrazine (114-83-0)

Conditions	Yield
bei der Einwirkung auf Phenylhydrazinnatrium;

acetic anhydride (108-24-7) + phenylhydrazine (100-63-0) + benzene (71-43-2) → 1-acetyl-2-phenylhydrazine (114-83-0)

phenylhydrazine acetate (72358-76-0) → 1-acetyl-2-phenylhydrazine (114-83-0)

Conditions	Yield
at 80 - 90℃;

Acetyl cyanide (631-57-2) + propionic acid (802294-64-0) + phenylhydrazine (100-63-0) → 1-acetyl-2-phenylhydrazine (114-83-0)

ethyl acetate (141-78-6) + phenylhydrazine (100-63-0) → 1-acetyl-2-phenylhydrazine (114-83-0)

Conditions	Yield
at 170℃; im Druckrohr;

phenyl-hydrazine; sodium-compound (59105-56-5) + acetyl chloride (75-36-5) → N'-acetyl-N'-phenylacetohydrazide (38604-74-9) + 1-acetyl-2-phenylhydrazine (114-83-0)

chloroacetyl chloride (79-04-9) + 1-acetyl-2-phenylhydrazine (114-83-0) → 2-acetyl-1-(2-chloroacetyl)phenylhydrazine (108511-46-2)

Conditions	Yield
In dichloromethane for 0.5h;	100%
With benzene

acetic anhydride (108-24-7) + 1-acetyl-2-phenylhydrazine (114-83-0) → N'-acetyl-N'-phenylacetohydrazide (38604-74-9)

Conditions	Yield
	99%

trimethyl(pentafluorophenyl)silane (1206-46-8) + 1-acetyl-2-phenylhydrazine (114-83-0) → Pentafluorobenzene (363-72-4) + trimethylsilyl acetate phenyl(trimethylsilyl)hydrazone

Conditions	Yield
With (K-18-crown-6 ether) cyanide In acetonitrile at 20℃; for 8h; sealed evacuated ampul;	A n/a B 98%

1-acetyl-2-phenylhydrazine (114-83-0) → 1-methyl-3-phenyl-2,3-diazaprop-2-en-1-one (13443-97-5)

Conditions	Yield
With pyridine; manganese(IV) oxide; bromine In dichloromethane at 0℃;	98%
With pyridine; N-Bromosuccinimide In dichloromethane for 0.5h; Ambient temperature;	79%
With potassium hexacyanoferrate(III) In sodium hydroxide; dichloromethane	19%

iodobenzene (591-50-4) + 1-acetyl-2-phenylhydrazine (114-83-0) → 1-acetyl-1,2-diphenylhydrazine (22293-38-5)

Conditions	Yield
With potassium phosphate; copper(l) iodide; 3-amino propanoic acid In 1,4-dioxane at 100℃; for 24h; Goldberg reaction;	98%

Lawessons reagent (19172-47-5) + 1-acetyl-2-phenylhydrazine (114-83-0) → 2-(4-Methoxy-phenyl)-5-methyl-3-phenyl-3H-[1,3,4,2]thiadiazaphosphole 2-sulfide (79201-96-0)

Conditions	Yield
In benzene at 80℃; for 10h;	97%

methyl 2-diazo-4-methoxy-3-oxobutanoate (105940-00-9) + 1-acetyl-2-phenylhydrazine (114-83-0) → methyl 1-acetamido-2-(methoxymethyl)-1H-indole-3-carboxylate (1610689-74-1)

Conditions	Yield
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; acetic acid In water at 100℃; for 0.5h; Inert atmosphere; Schlenk technique; Sealed tube;	95%

1-acetyl-2-phenylhydrazine (114-83-0) + 2-(dimethyl(oxo)-λ6-sulfaneylidene)-1-(furan-2-yl)ethan-1-one → C14H12N2O2

Conditions	Yield
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; sodium acetate; acetic acid; silver(I) triflimide In 1,2-dichloro-ethane at 100℃; for 12h; Inert atmosphere;	95%

trimethyl(pentafluorophenyl)silane (1206-46-8) + 1-acetyl-2-phenylhydrazine (114-83-0) → Pentafluorobenzene (363-72-4) + 1-trimethylsiloxyethanone phenylhydrazone (92773-30-3)

Conditions	Yield
With (K-18-crown-6 ether) cyanide In acetonitrile at 20℃; for 1h; sealed evacuated ampul;	A n/a B 94%

1,2-bis(4-methylphenyl)acetylene (2789-88-0) + 1-acetyl-2-phenylhydrazine (114-83-0) → N-(2,3-di-p-tolyl-1H-indol-1-yl)acetamide

Conditions	Yield
With meta-dinitrobenzene; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; sodium acetate In 1,2-dichloro-ethane at 60℃; Sealed tube; Inert atmosphere; Schlenk technique; regioselective reaction;	94%

N-(4-methoxyphenyl)maleimide (1081-17-0) + 1-acetyl-2-phenylhydrazine (114-83-0) → N-(2-(4-methoxyphenyl)-1,3-dioxo-2,3-dihydropyrrolo[3,4-b]indol-4(1H)-yl)acetamide

Conditions	Yield
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver carbonate; silver(I) triflimide In 1,2-dichloro-ethane at 90℃; for 6h; Inert atmosphere;	94%

1,2-bis(4-methylphenyl)acetylene (2789-88-0) + 1-acetyl-2-phenylhydrazine (114-83-0) → 2,3-bis(4-methylphenyl)-1H-indole

Conditions	Yield
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; acetic acid In 1,2-dichloro-ethane at 70℃; for 16h; Inert atmosphere;	93%

7-methylbenzofuran (17059-52-8) + 1-acetyl-2-phenylhydrazine (114-83-0) → 7-methyl-2-phenylbenzofuran (50543-55-0)

Conditions	Yield
With dichloro bis(acetonitrile) palladium(II); 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In 1,4-dioxane at 100℃; for 24h; regioselective reaction;	93%

2-(dimethyl(oxo)-λ6-sulfaneylidene)-1-phenylethan-1-one (20718-17-6) + 1-acetyl-2-phenylhydrazine (114-83-0) → N-(2-phenyl-1H-indol-1-yl)acetamide

Conditions	Yield
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; sodium acetate; acetic acid; silver(I) triflimide In 1,2-dichloro-ethane at 100℃; for 12h; Catalytic behavior; Reagent/catalyst; Solvent; Inert atmosphere;	93%
With tris(acetonitrile)(η5-pentamethylcyclopentadienyl)rhodium(III) hexafluoroantimonate; zinc diacetate In 1,2-dichloro-ethane at 100℃; for 16h; Schlenk technique; Inert atmosphere;	82%
With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; sodium acetate In tetrahydrofuran at 100℃; for 20h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; Sealed tube;	82%

2-(dimethyl(oxo)-λ6-sulfaneylidene)-1-(thiophen-2-yl)ethan-1-one + 1-acetyl-2-phenylhydrazine (114-83-0) → N-(2-(thiophen-2-yl)-1H-indol-1-yl)acetamide

Conditions	Yield
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; sodium acetate; acetic acid; silver(I) triflimide In 1,2-dichloro-ethane at 100℃; for 12h; Inert atmosphere;	93%
With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; sodium acetate In tetrahydrofuran at 100℃; for 20h; Inert atmosphere; Sealed tube;	63%

1-(3-methylphenyl)-1H-pyrrole-2,5-dione (20299-79-0) + 1-acetyl-2-phenylhydrazine (114-83-0) → N-(1,3-dioxo-2-(m-tolyl)-2,3-dihydropyrrolo[3,4-b]indol-4(1H)-yl)acetamide

Conditions	Yield
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver carbonate; silver(I) triflimide In 1,2-dichloro-ethane at 90℃; for 6h; Inert atmosphere;	93%

diphenyl acetylene (501-65-5) + 1-acetyl-2-phenylhydrazine (114-83-0) → N-(2,3-diphenyl-1H-indol-1-yl)acetamide

Conditions	Yield
With meta-dinitrobenzene; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; sodium acetate In 1,2-dichloro-ethane at 60℃; for 24h; Catalytic behavior; Reagent/catalyst; Solvent; Sealed tube; Inert atmosphere; Schlenk technique; regioselective reaction;	92%

4,4'-dimethoxydiphenylacetylene (2132-62-9) + 1-acetyl-2-phenylhydrazine (114-83-0) → indoxole (5034-76-4)

Conditions	Yield
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; acetic acid In 1,2-dichloro-ethane at 70℃; for 16h; Inert atmosphere;	91%

1,2-bis(4-fluorophenyl)acetylene (5216-31-9) + 1-acetyl-2-phenylhydrazine (114-83-0) → 2,3-bis(4-fluorophenyl)-1H-indole (628320-79-6)

Conditions	Yield
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; acetic acid In 1,2-dichloro-ethane at 70℃; for 16h; Inert atmosphere;	91%

ethyl 2-diazo-3-oxobutanoate (2009-97-4) + 1-acetyl-2-phenylhydrazine (114-83-0) → ethyl 1-acetamido-2-methyl-1H-indole-3-carboxylate (1610689-50-3)

Conditions	Yield
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; acetic acid In water at 100℃; for 1h; Reagent/catalyst; Concentration; Solvent; Time; Inert atmosphere; Schlenk technique; Sealed tube;	91%

2-Diazo-3-oxo-butyric acid methyl ester (24762-04-7) + 1-acetyl-2-phenylhydrazine (114-83-0) → methyl 1-acetamido-2-methyl-1H-indole-3-carboxylate (1610689-73-0)

Conditions	Yield
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; acetic acid In water at 100℃; for 1h; Inert atmosphere; Schlenk technique; Sealed tube;	91%

5-methoxybenzofuran (13391-28-1) + 1-acetyl-2-phenylhydrazine (114-83-0) → 2-phenyl-5-methoxybenzo[b]furan (7182-32-3)

Conditions	Yield
With dichloro bis(acetonitrile) palladium(II); 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In 1,4-dioxane at 100℃; for 24h; regioselective reaction;	91%

N-phenyl-maleimide (941-69-5) + 1-acetyl-2-phenylhydrazine (114-83-0) → N-(1,3-dioxo-2-phenyl-2,3,3a,8b-tetrahydropyrrolo[3,4-b]indol-4(1H)-yl)acetamide

Conditions	Yield
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver carbonate; silver(I) triflimide In 1,2-dichloro-ethane at 90℃; for 6h; Inert atmosphere;	91%

1-acetyl-2-phenylhydrazine (114-83-0) → 5-methyl-2-bromo-3-phenyl-2,3-dihydro-1,3,4,2-oxadiazaphosphole

Conditions	Yield
With phosphorus pentabromide; triethylamine In benzene at 5 - 60℃; for 2h;	90%

1-bromo-4-ethenyl-benzene (2039-82-9) + 1-acetyl-2-phenylhydrazine (114-83-0) → (E)-4-bromostilbene (13041-70-8)

Conditions	Yield
With copper(l) iodide; trifluoroacetic acid; palladium dichloride In dimethyl sulfoxide at 80℃;	90%

Upstream product

• 28286-72-8 acetyl-methyl-malonic acid diethyl ester 
• 72358-76-0 phenylhydrazine acetate 
• 631-57-2 Acetyl cyanide 
• 802294-64-0 propionic acid 
• 100-63-0 phenylhydrazine 
• 141-78-6 ethyl acetate 
• 60-29-7 diethyl ether 
• 75-36-5 acetyl chloride 
• 463-51-4 Ketene 
• 79-21-0 peracetic acid 
• 108-05-4 vinyl acetate 
• 120-80-9 benzene-1,2-diol 
• 99049-24-8 2-(diethylamino)-5-methyl-3-phenyl-2-(phenylimino)-Δ⁴-1,3,4,2λ⁵-oxadiazaphospholine 
• 99049-28-2 N-cyclohexyl-N'-phenylphosphorodiamidic 2-acetyl-1-phenylhydrazide 

Downstream Products

• 14575-62-3 5-methyl-1-phenyl-1,2-dihydro-pyrazol-3-one 
• 19735-89-8 3-methyl-1-phenylpyrazolin-5(4H)-one 
• 38604-74-9 N'-acetyl-N'-phenylacetohydrazide 
• 42141-09-3 1,5-diphenyl-3-methyl-1H-1,2,4-triazole 
• 41217-48-5 3,5-dimethyl-1-phenyl-1H-1,2,4-triazole 
• 24660-33-1 N'-acetyl-N-phenyl-N-p-toluoyl-hydrazine 
• 56616-95-6 1H-5-methyl-1-phenyl-1,2,4-triazole 
• 62762-06-5 2,5-dimethyl-3-phenyl-2,3-dihydro-[1,3,4,2]oxadiazaphosphole 2-oxide 
• 55498-95-8 2,2-dichloro-2,5-dimethyl-3-phenyl-2,3-dihydro-2λ⁵-[1,3,4,2]oxadiazaphosphole 
• 19525-44-1 2-Chloro-5-methyl-3-phenyl-Δ⁴-1,3,4,2-oxadiazaphospholine 
• 55498-94-7 2,2,2-trichloro-5-methyl-3-phenyl-2,3-dihydro-2λ⁵-[1,3,4,2]oxadiazaphosphole 
• 108306-12-3 N¹-Acetyl-N¹-(5,6-diphenyl-1,2,4-triazin-3-yl)-N²-phenylhydrazine 
• 42108-38-3 N-acetyl-N,N'-dimethyl-N'-phenylhydrazine 
• 38604-70-5 1-acetyl-1-methyl-2-phenylhydrazine 

Related news

The haemolytic reactions of 1-Acetyl-2-phenylhydrazine (cas 114-83-0) and hydrazine: A spin trapping study08/23/2019

Free radical production from the reaction of hydrazine and 1-acetyl-2-phenylhydrazine (AcPhHZ) with oxyhaemoglobin and with human red blood cells, has been observed by the electron spin resonance technique of spin trapping. Using the spin trap 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), the free ra...detailed

Effect of copper(II) and iron(III) ions on reactions undergone by the accelerator 1-Acetyl-2-phenylhydrazine (cas 114-83-0) commonly used in anaerobic adhesives08/22/2019

The reactions of 1-acetyl-2-phenylhydrazine, an accelerator used in anaerobic adhesives, were studied in the presence of transition metal ions and typical cure components. The reaction compounds have been identified and a novel cure mechanism is proposed.detailed

Relevant articles and documents

A formal [3+2] cycloaddition reaction of: N -methylimidazole as a masked hydrogen cyanide: Access to 1,3-disubstitued-1 H -1,2,4-triazoles

N-Methylimidazole (NMI) can act as a masked HCN in the synthesis of 1,3-disubstitued-1H-1,2,4-triazoles via a formal cycloaddition reaction of hydrazonoyl chloride with NMI. The product was proved to be formed via an initial nucleophilic substitution of hydrazonoyl chloride with NMI following cyclization and two sequential C-N bond cleavages. This journal is

The impact of cation structure upon the acidity of triazolium salts in dimethyl sulfoxide

A series of triazolium salts, selected for their varying electronic and steric properties, were prepared and their pKa values were determined in DMSO at 25 °C using the bracketing indicator method. The effect of each systematic structural variation upon the acidity of the triazolium cation has been considered, in particular examining the effects of systematically altering electronic properties, quantified through the use of Hammett σ parameters. The first pKa value for an azolium salt that generates a mesionic carbene is also reported. These new data allow for the selection of appropriate bases for the deprotonation of such triazolium salts and the potential to correlate the pKa values determined herein with the nucleophilicity of the corresponding carbenes.

Synthesis method for organic synthesis of intermediate acetyl phenylhydrazine

The invention relates to a synthesis method for organic synthesis of an intermediate acetyl phenylhydrazine. The method mainly includes the steps of: adding 3mol phenylhydrazine into a reaction container and 4-5mol p-iodoacetanilide into a reaction container, performing heating to 90-95DEG C, conducting reflux for 130-150min, lowering temperature to 10-15DEG C, filtering the crystal, conducting washing with a methylamine solution and a dichloromethane solution respectively, performing recrystallization in an ethanol solution, precipitating crystals, conducting filtration, and performing dehydration with a dehydrating agent, thus obtaining the finished product acetyl phenylhydrazine.