Ethyl 2-[4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl]phenoxy]acetate

Base Information

• Chemical Name: Ethyl 2-[4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl]phenoxy]acetate
• CAS No.: 64985-43-9
• Molecular Formula: C₂₀H₁₉NO₅
• Molecular Weight: 353.375
• DSSTox Substance ID: DTXSID801142912
• Nikkaji Number: J1.437.556B

Synonyms:SCHEMBL11379270;DTXSID801142912;64985-43-9;Ethyl 2-[4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl]phenoxy]acetate

Chemical Property of Ethyl 2-[4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl]phenoxy]acetate

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 8
• Exact Mass: 353.12632271
• Heavy Atom Count: 26
• Complexity: 502

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC(=O)COC1=CC=C(C=C1)CCN2C(=O)C3=CC=CC=C3C2=O

Technology Process of Ethyl 2-[4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl]phenoxy]acetate

There total 2 articles about Ethyl 2-[4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl]phenoxy]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-(2-(4-hydroxyphenyl)ethyl) isoindolin-1,3-dione (64985-42-8) + ethyl bromoacetate (105-36-2) → ethyl {4-[2-(1,3-dioxo-2,3-dihydro-1H-2-isoindolyl)ethyl]phenoxy}acetate (64985-43-9)

Guidance literature:

With tetrabutylammomium bromide; potassium carbonate; for 0.116667h; Further Variations:; Reaction partners; Solvents; Temperatures; Product distribution; microwave irradiation;

DOI:10.1080/00397910008086969

Reference yield:

→ ethyl {4-[2-(1,3-dioxo-2,3-dihydro-1H-2-isoindolyl)ethyl]phenoxy}acetate (64985-43-9)

Guidance literature:

Bromessigester, entspr. Phenol;

Reference yield:

ethyl {4-[2-(1,3-dioxo-2,3-dihydro-1H-2-isoindolyl)ethyl]phenoxy}acetate (64985-43-9) → {4-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-phenoxy}-acetic acid

Guidance literature:

With hydrogenchloride; acetic acid; at 20 ℃;

DOI:10.1016/S0960-894X(02)00203-2

upstream raw materials:

2-(2-(4-hydroxyphenyl)ethyl) isoindolin-1,3-dione

ethyl bromoacetate

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