6-Methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carboxylic acid

Base Information

• Chemical Name: 6-Methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carboxylic acid
• CAS No.: 24667-07-0
• Molecular Formula: C₈H₆F₃NO₃
• Molecular Weight: 221.136
• NSC Number: 71057
• DSSTox Substance ID: DTXSID90290791
• Wikidata: Q82028579
• Mol file: 24667-07-0.mol

Synonyms:24667-07-0;6-methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carboxylic acid;NSC 71057;NSC71057;DTXSID90290791;NSC-71057;AKOS000320140;CS-0529447;EN300-9533153;2-Hydroxy-6-methyl-4-(trifluoromethyl)nicotinic acid

Chemical Property of 6-Methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carboxylic acid

Chemical Property:

• Vapor Pressure: 3.67E-05mmHg at 25°C
• Boiling Point: 328.7°Cat760mmHg
• Flash Point: 152.6°C
• Density: 1.526g/cm³
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 1
• Exact Mass: 221.02997754
• Heavy Atom Count: 15
• Complexity: 392

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C(=O)N1)C(=O)O)C(F)(F)F

Technology Process of 6-Methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carboxylic acid

There total 4 articles about 6-Methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxy-6-methyl-4-(trifluoromethyl)-3-pyridinecarbonitrile (654-49-9) + methyl iodide (74-88-4) → 2-hydroxy-6-methyl-4-(trifluoromethyl)nicotinic acid (24667-07-0)

Guidance literature:

With sodium hydroxide; at 25 - 140 ℃; for 24h;

DOI:10.1021/acsmedchemlett.1c00448

Reference yield:

C9H8F3NO3 (1421673-57-5) → 6-methyl-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carboxylic acid (24667-07-0)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; for 48h; Reflux;

DOI:10.1016/j.bmcl.2012.12.019

Reference yield:

→ 2-hydroxy-6-methyl-4-(trifluoromethyl)nicotinic acid (24667-07-0)

Guidance literature:

6-Hydroxy-2-methyl-4-trifluormethyl-5-cyan-pyridin, wss. KOH;

DOI:10.1021/jm00339a017

upstream raw materials:

2-hydroxy-6-methyl-4-(trifluoromethyl)-3-pyridinecarbonitrile

methyl iodide

C₉H₈F₃NO₃

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