2-Hydroxy-4'-methylbenzophenone

Base Information

• Chemical Name: 2-Hydroxy-4'-methylbenzophenone
• CAS No.: 19434-30-1
• Molecular Formula: C14H12O2
• Molecular Weight: 212.248
• DSSTox Substance ID: DTXSID50173056
• Nikkaji Number: J232.162I
• Wikidata: Q83043160
• Mol file: 19434-30-1.mol

Synonyms:2-Hydroxy-4'-methylbenzophenone;BRN 2259499;BENZOPHENONE, 2-HYDROXY-4'-METHYL-;19434-30-1;SCHEMBL3483879;2'-hydroxy-4-methylbenzophenone;DTXSID50173056;LS-38931

Chemical Property of 2-Hydroxy-4'-methylbenzophenone

Chemical Property:

• Vapor Pressure: 3.32E-05mmHg at 25°C
• Boiling Point: 344.4°C at 760 mmHg
• Flash Point: 146.6°C
• Density: 1.164g/cm³
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 212.083729621
• Heavy Atom Count: 16
• Complexity: 241

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C(=O)C2=CC=CC=C2O

Technology Process of 2-Hydroxy-4'-methylbenzophenone

There total 63 articles about 2-Hydroxy-4'-methylbenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-(1-hydroxy-3-phenyl-1-(p-tolyl)prop-2-yn-1-yl)phenol → 1,4-diphenyl-1,3-butadiyne (886-66-8) + 2-hydroxy-4'-methylbenzophenone (19434-30-1)

Guidance literature:

With copper(II) acetate monohydrate; In acetonitrile; for 3h; Reflux;

DOI:10.3184/174751913X13739011239995

Reference yield: 73.0%

2-(((4-methylphenyl)sulfonyl)oxy)benzoic acid (82745-72-0) → 2-hydroxy-4'-methylbenzophenone (19434-30-1)

Guidance literature:

With dipotassium hydrogenphosphate; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; triphenylphosphine; In tetrahydrofuran; at 25 ℃; for 8h; Schlenk technique; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1002/chem.201903816

Reference yield: 5.0%

2-(allyloxy)-4'-methylbenzophenone (133366-98-0) → 2-methyldibenzofuran (7320-51-6) + 3-methyl-9H-xanthen-9-one (19814-98-3) + 2-methyl-9H-xanthen-9-one (6280-45-1) + 2-hydroxy-4'-methylbenzophenone (19434-30-1)

Guidance literature:

at 750 ℃; for 2.16667h; under 0.005 Torr; Further byproducts given;

upstream raw materials:

(5-(tert-butyl)-2-hydroxyphenyl)(p-tolyl)methanone

5-tert-butyl-2-methoxy-4'-methyl-benzophenone

2-Methoxybenzoyl chloride

toluene

Downstream raw materials:

3-acetyl-4-(p-tolyl)-2H-chromen-2-one

(S)-2-(amino(p-tolyl)methyl)phenol

(E)-2-(p-tolyl((3,4,5-trimethoxyphenyl)imino)methyl)phenol

(S)-2-(p-tolyl((3,4,5-trimethoxyphenyl)amino)methyl)phenol

Refernces

• 1、 Xiao, Lin,Lang, Tao-Tao,Jiang, Ying,Zang, Zhong-Lin,Zhou, Cheng-He,Cai, Gui-Xin. "Aerobic Copper-Catalyzed Salicylaldehydic Cformyl?H Arylations with Arylboronic Acids". supporting information. p. 3278 - 3283. Retrieved 2021/02/01.
• 2、 Hu, Le' an,Zhang, Yao,Zhang, Qing-Wen,Yin, Qin,Zhang, Xumu. "Ruthenium-Catalyzed Direct Asymmetric Reductive Amination of Diaryl and Sterically Hindered Ketones with Ammonium Salts and H2". . p. 5321 - 5325. Retrieved 2020/02/28.