dl-α-Prodine

Base Information

• Chemical Name: dl-α-Prodine
• CAS No.: 15867-21-7
• Molecular Formula: C₁₆H₂₃NO₂
• Molecular Weight: 261.364
• Mol file: 15867-21-7.mol

Synonyms:4-Piperidinol,1,3-dimethyl-4-phenyl-,propanoate (ester),cis-(+-);(+-)-Alphaprodine;Alphaprodine;

Chemical Property of dl-α-Prodine

Chemical Property:

• Boiling Point: 338.4°Cat760mmHg
• Flash Point: 110.3°C
• PSA: 29.54000
• Density: 1.06g/cm³
• LogP: 2.74460

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of dl-α-Prodine

There total 5 articles about dl-α-Prodine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-dimethyl-4-piperidinone (4629-80-5) → (+/-)-β-prodine (77-20-3,468-59-7,15867-21-7,23950-19-8,25123-05-1,25123-06-2,25312-58-7,25312-59-8,51264-03-0) + (+/-)-α-prodine (77-20-3,468-59-7,15867-21-7,23950-19-8,25123-05-1,25123-06-2,25312-58-7,25312-59-8,51264-03-0)

Guidance literature:

With diethyl ether; phenyllithium;

DOI:10.1021/jo01170a024

Reference yield:

1,3-dimethyl-4-piperidinone (4629-80-5) → (+/-)-β-prodine (77-20-3,468-59-7,15867-21-7,23950-19-8,25123-05-1,25123-06-2,25312-58-7,25312-59-8,51264-03-0) + (+/-)-α-prodine (77-20-3,468-59-7,15867-21-7,23950-19-8,25123-05-1,25123-06-2,25312-58-7,25312-59-8,51264-03-0)

Guidance literature:

With diethyl ether; phenyllithium;

DOI:10.1021/jo01170a024

Reference yield:

6-ethyl-3-methyl-6-phenyl-[1,3]oxazinane (51412-30-7) + propionic acid anhydride (123-62-6) → (+/-)-α-prodine (77-20-3,468-59-7,15867-21-7,23950-19-8,25123-05-1,25123-06-2,25312-58-7,25312-59-8,51264-03-0)

Guidance literature:

With sulfuric acid; Das Produkt ist ein Gemisch der Stereoisomeren;

upstream raw materials:

1,3,5-trimethyl-1,3,5-triazacyclohexane

1-ethylstyrene

propionic acid anhydride

1,3-dimethyl-4-piperidinone

Downstream raw materials:

(+/-)-α-4-acetoxy-3-methyl-4-phenyl-1-(1-phenylcyclohexyl)piperidine

(+/-)-α-4-hydroxy-3-methyl-4-phenyl-1-(1-phenylcyclohexyl)piperidine

(+/-)-α-1-(1-cyanocyclohexyl)-4-hydroxy-3-methyl-4-phenylpiperidine

α-4-hydroxy-3-methyl-4-phenyl-1-propanoylpiperidine

Refernces