2-[(2-Chloroacetyl)(methyl)amino]acetic acid

Base Information

• Chemical Name: 2-[(2-Chloroacetyl)(methyl)amino]acetic acid
• CAS No.: 65332-01-6
• Molecular Formula: C5H8ClNO3
• Molecular Weight: 165.576
• Hs Code.: 2922499990
• Mol file: 65332-01-6.mol

Synonyms:N-Chloracetyl-N-methyl-glycin;N-chloroacetyl-2-pyrrolidinone;N-chloroacetyl-N-methyl-glycine;N-chloroacetylsarcosine;Chloracetyl-sarkosin;

Chemical Property of 2-[(2-Chloroacetyl)(methyl)amino]acetic acid

Chemical Property:

• PSA: 57.61000
• LogP: -0.23180

Purity/Quality:

98%min ^*data from raw suppliers

2-[(2-Chloroacetyl)(methyl)amino]aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[(2-Chloroacetyl)(methyl)amino]acetic acid

There total 3 articles about 2-[(2-Chloroacetyl)(methyl)amino]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

sarcosine (107-97-1,25951-24-0) + chloroacetyl chloride (79-04-9) → methyl N-(2-chloroacetyl)glycine (65332-01-6)

Guidance literature:

With sodium carbonate; In dichloromethane; water;

DOI:10.1016/j.tetlet.2011.01.138

Reference yield:

sarcosine (107-97-1,25951-24-0) + chloroacetyl chloride (79-04-9) → N-(Chloroacetyl)sarosine + methyl N-(2-chloroacetyl)glycine (65332-01-6)

Guidance literature:

In ethyl acetate;

Reference yield:

glycine hydrogen chloride + Chloroacetic anhydride (541-88-8) → methyl N-(2-chloroacetyl)glycine (65332-01-6)

Guidance literature:

upstream raw materials:

sarcosine

chloroacetyl chloride

Chloroacetic anhydride

Downstream raw materials:

Glycylsarcosine

3-methoxy-2-(4-methyl-2,5-dioxo-piperazin-1-yl)-benzoic acid methyl ester

C₁₄H₁₇ClN₂O₅

1-benzyl-3,6-dibromo-4-methylpiperazine-2,5-dione