N,N-Dimethylphthalamidic acid methyl ester

Base Information

• Chemical Name: N,N-Dimethylphthalamidic acid methyl ester
• CAS No.: 26593-43-1
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.229
• Hs Code.: 2924299090
• Mol file: 26593-43-1.mol

Synonyms:Phthalamicacid, N,N-dimethyl-, methyl ester (8CI);2-Methoxycarbonyl-N,N-dimethylbenzamide

Chemical Property of N,N-Dimethylphthalamidic acid methyl ester

Chemical Property:

• Vapor Pressure: 3.15E-05mmHg at 25°C
• Boiling Point: 355.3°C at 760 mmHg
• Flash Point: 168.7°C
• PSA: 46.61000
• Density: 1.134g/cm³
• LogP: 1.17500

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-Dimethylphthalamidic acid methyl ester

There total 2 articles about N,N-Dimethylphthalamidic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phthalic monoacid monomethyl ester chloride (4397-55-1) + dimethyl amine (124-40-3) → 2-methoxycarbonyl-N,N-dimethylbenzamide (26593-43-1)

Guidance literature:

Reference yield:

→ 2-methoxycarbonyl-N,N-dimethylbenzamide (26593-43-1)

Guidance literature:

Phthalsaeureanhydrid/MeOH, 1.) SOCl2, 2.) Me2NH/Py.;

DOI:10.1007/BF00761337

Reference yield: 36.0%

2-methoxycarbonyl-N,N-dimethylbenzamide (26593-43-1) + chromium(0) hexacarbonyl (199620-14-9,13007-92-6) → pentacarbonyl[(N,N-dimethylamino)(2-methoxycarbonylphenyl)carbene]chromium(0)

Guidance literature:

With sodium naphthalenide; trimethylchlorosilane; In tetrahydrofuran; byproducts: naphthalene; (Ar) Cr(CO)6 in THF, NaC10H7 in THF at -78°C, stirred for 30 min at 0°C, benzamide-compound in THF was added at -78°C, stirred for 30 min at 0°C, (CH3)3SiCl was added at -78°C, stirred for 30 min, 1 h at room temp.; neutral alumina was added, THF was removed under reduced pressure, driedunder high vac., hexane was added, the suspn. was transferred on the to p of a silica gel column, eluted with hexane (naphthalene), then CH2Cl2-hexane 1:1; elem. anal.;

DOI:10.1021/om701188p

upstream raw materials:

phthalic monoacid monomethyl ester chloride

dimethyl amine