Phenol, 4-methyl-2-[(1-methyl-1H-benzimidazol-2-yl)azo]-

Base Information

• Chemical Name: Phenol, 4-methyl-2-[(1-methyl-1H-benzimidazol-2-yl)azo]-
• CAS No.: 65446-32-4
• Molecular Formula: C15H14N4O
• Molecular Weight: 266.302
• DSSTox Substance ID: DTXSID60425694
• Nikkaji Number: J3.226.296A
• Mol file: 65446-32-4.mol

Synonyms:Phenol, 4-methyl-2-[(1-methyl-1H-benzimidazol-2-yl)azo]-;65446-32-4;DTXSID60425694;2-(1-Methyl-1H-benzoimidazole-2-ylazo)-p-cresol;4-methyl-2-[(1-methylbenzimidazol-2-yl)diazenyl]phenol

Chemical Property of Phenol, 4-methyl-2-[(1-methyl-1H-benzimidazol-2-yl)azo]-

Chemical Property:

• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 266.11676108
• Heavy Atom Count: 20
• Complexity: 362

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1)O)N=NC2=NC3=CC=CC=C3N2C

Technology Process of Phenol, 4-methyl-2-[(1-methyl-1H-benzimidazol-2-yl)azo]-

There total 6 articles about Phenol, 4-methyl-2-[(1-methyl-1H-benzimidazol-2-yl)azo]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

p-cresol (106-44-5) + 1-methylbenzimidazole-2-diazonium phosphate → 2-(2'-hydroxy-4-methylphenylazo)-1-methylbenzimidazole (65446-32-4) + 2-(2-Methyl-5-hydroxyphenylazo)-1-methylbenzimidazole (137676-62-1)

Guidance literature:

In water; acetic acid;

DOI:10.1007/BF00487430

Reference yield: 62.0%

C14H12N4O + methyl iodide (74-88-4) → 2-(2'-hydroxy-4-methylphenylazo)-1-methylbenzimidazole (65446-32-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran;

DOI:10.1016/j.saa.2013.06.049

Reference yield: 20.0%

p-cresol (106-44-5) + 2-Amino-1-methylbenzimidazole (1622-57-7) → 2-(2'-hydroxy-4-methylphenylazo)-1-methylbenzimidazole (65446-32-4)

Guidance literature:

2-Amino-1-methylbenzimidazole; With phosphoric acid; sodium nitrite; In water; for 0.5h;

p-cresol; In water; for 0.5h;

With sodium carbonate; In water; pH=7 - 8; Cooling with ice;

DOI:10.1080/00958971003690421

upstream raw materials:

p-cresol

2-Amino-1-methylbenzimidazole

methyl iodide

3-amino-4-hydroxytoluene