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1622-57-7

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1622-57-7 Usage

Chemical Properties

white to beige fine crystalline powder

Uses

2-Amino-1-methylbenzimidazole may be used for the preparation of 2- or 3-carboxy-4H-pyrimido[2,1-b]-benzazol-4-ones and novel functionalized spiropyran′s derivatives of 2H-1,3-benzoxazinone series.

General Description

The carbonyl-scavenging ability of 2-amino-1-methylbenzimidazole has been investigated. Mechanism of Menshutkin reaction between 2-amino-1-methylbenzimidazole and iodomethane has been studied in gas phase and in liquid acetonitrile. It is reported to form adducts with natural allyl, phenethyl, and benzyl isothiocyanates.

Check Digit Verification of cas no

The CAS Registry Mumber 1622-57-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,2 and 2 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1622-57:
(6*1)+(5*6)+(4*2)+(3*2)+(2*5)+(1*7)=67
67 % 10 = 7
So 1622-57-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H9N3/c1-11-7-5-3-2-4-6(7)10-8(11)9/h2-5H,1H3,(H2,9,10)

1622-57-7 Well-known Company Product Price

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  • Aldrich

  • (412546)  2-Amino-1-methylbenzimidazole  95%

  • 1622-57-7

  • 412546-1G

  • 620.10CNY

  • Detail
  • Aldrich

  • (412546)  2-Amino-1-methylbenzimidazole  95%

  • 1622-57-7

  • 412546-5G

  • 2,155.14CNY

  • Detail

1622-57-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Amino-1-methylbenzimidazole

1.2 Other means of identification

Product number -
Other names 1-methylbenzimidazol-2-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1622-57-7 SDS

1622-57-7Relevant articles and documents

2-aminobenzimidazoles for leishmaniasis: From initial hit discovery to in vivo profiling

Ferreira, Rafael Augusto Alves,Junior, Celso de Oliveira Rezende,Martinez, Pablo David Grigol,Koovits, Paul John,Soares, Bruna Miranda,Ferreira, Leonardo L. G.,Michelan-Duarte, Simone,Chelucci, Rafael Consolin,Andricopulo, Adriano D.,Galuppo, Mariana K.,Uliana, Silvia R. B.,Matheeussen, An,Caljon, Guy,Maes, Louis,Campbell, Simon,Kratz, Jadel M.,Mowbray, Charles E.,Dias, Luiz Carlos

, (2021/03/24)

Leishmaniasis is a major infectious disease with hundreds of thousands of new cases and over 20,000 deaths each year. The current drugs to treat this life-threatening infection have several drawbacks such as toxicity and long treatment regimens. A library of 1.8 million compounds, from which the hits reported here are publicly available, was screened against Leishmania infantum as part of an optimization program; a compound was found with a 2-aminobenzimidazole functionality presenting moderate potency, low metabolic stability and high lipophilicity. Several rounds of synthesis were performed to incorporate chemical groups capable of reducing lipophilicity and clearance, leading to the identification of compounds that are active against different parasite strains and have improved in vitro proper-ties. As a result of this optimization program, a group of compounds was further tested in anticipation of in vivo evaluation. In vivo tests were carried out with compounds 29 (L. infantum IC50: 4.1 μM) and 39 (L. infantum IC50: 0.5 μM) in an acute L. infantum VL mouse model, which showed problems of poor exposure and lack of efficacy, despite the good in vitro potency.

HMOX1 inducers

-

Page/Page column 21; 159, (2020/09/18)

The present invention is related to compounds of structure (I) as heme oxygenase 1 (HMOX 1) inducers. The present invention is also related a method of controlling the activity or the amount, or both the activity and the amount, of heme-oxygenase 1 in a mammalian subject. The definitions of the variables are provided herein.

Metal-free C(sp2)-H functionalization of azoles: K2CO3/I2-mediated oxidation, imination, and amination

Das, Ranajit,Banerjee, Mainak,Rai, Rakesh Kumar,Karri, Ramesh,Roy, Gouriprasanna

, p. 4243 - 4260 (2018/06/22)

The direct C2-H oxidation and imination of a wide variety of azoles was achieved by using a commercially available simple K2CO3/I2 reagent combination. The iodinated azole adduct, produced via the in situ generation of N-heterocyclic carbene, is the key intermediate for C2-H oxidation, imination, and amination of azoles. Significantly, these reactions proceed under mild conditions with high to excellent yields, are scalable to large quantity and exhibit a broad substrate scope. Interestingly, this direct C2-H imination method allowed us to access various pharmacologically active N6-alkyl or N6-aryl substituted benzimidazoquinazolinone scaffolds through intramolecular C-H imination in a sequential one-pot reaction.

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