4-({[4-({[4-(formylamino)-1-methyl-1H-pyrrol-2-yl]carbonyl}amino)-1-methyl-1H-pyrrol-2-yl]carbonyl}amino)-1-methyl-1H-pyrrole-2-carboxylic acid

Base Information

Chemical Name:4-({[4-({[4-(formylamino)-1-methyl-1H-pyrrol-2-yl]carbonyl}amino)-1-methyl-1H-pyrrol-2-yl]carbonyl}amino)-1-methyl-1H-pyrrole-2-carboxylic acid
CAS No.:77716-21-3
Molecular Formula:C19H20N6O5
Molecular Weight:412.405
Hs Code.:

4-({[4-({[4-(formylamino)-1-methyl-1H-pyrrol-2-yl]carbonyl}amino)-1-methyl-1H-pyrrol-2-yl]carbonyl}amino)-1-methyl-1H-pyrrole-2-carboxylic acid

Synonyms:

Suppliers and Price of 4-({[4-({[4-(formylamino)-1-methyl-1H-pyrrol-2-yl]carbonyl}amino)-1-methyl-1H-pyrrol-2-yl]carbonyl}amino)-1-methyl-1H-pyrrole-2-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-({[4-({[4-(formylamino)-1-methyl-1H-pyrrol-2-yl]carbonyl}amino)-1-methyl-1H-pyrrol-2-yl]carbonyl}amino)-1-methyl-1H-pyrrole-2-carboxylic acid

Chemical Property:

Vapor Pressure:8.89E-16mmHg at 25°C
Boiling Point:610.9°Cat760mmHg
Flash Point:323.2°C
Density:1.45g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-({[4-({[4-(formylamino)-1-methyl-1H-pyrrol-2-yl]carbonyl}amino)-1-methyl-1H-pyrrol-2-yl]carbonyl}amino)-1-methyl-1H-pyrrole-2-carboxylic acid

There total 1 articles about 4-({[4-({[4-(formylamino)-1-methyl-1H-pyrrol-2-yl]carbonyl}amino)-1-methyl-1H-pyrrol-2-yl]carbonyl}amino)-1-methyl-1H-pyrrole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 77716-11-1
4-[(tert-butoxycarbonyl)amino]-1-methyl-1H-pyrrole-2-carboxylic acid

: 77716-21-3
4-(4-(4-formamido-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) aq. Cs₂CO₂ / 1) H₂O, EtOH; 2) DMF, 40 deg C, overnight

2: TFA / CH₂Cl₂ / 1 h

3: 1.) dicyclohexylcarbodiimide, HOBt, 2.) TEA / 1) CH₂Cl₂, 1 h; 2) CH₂Cl₂, 2 h, 0 deg C, 20 deg C (15 h)

4: 95 percent / H₂ / Pd/C / ethanol / 12 h

5: 59 percent / TFA, EDC / dimethylformamide / Ambient temperature

6: 77 percent / H₂ / Pd/C / dimethylformamide / 6 h / Ambient temperature

With TEA; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/jps.2600781106

Reference yield: 43.0%

: 77716-21-3
4-(4-(4-formamido-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxylic acid

: 83209-86-3
glycyl-anilinoacridine

: 4-(9-acridinylamino)-N-<4-<<<4-<<<4-(formylamino)-1-methyl-pyrrol-2-yl>carbonyl>amino>-1-methyl-pyrrol-2-yl>carbonyl>amino>-1-methyl-pyrrol-2-carbonyl>glycylaniline hydrochloride

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 ℃; for 18h;
DOI:10.1002/jps.2600781106

Reference yield:

: 77716-21-3
4-(4-(4-formamido-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxylic acid

: 6576-51-8
distamycin A hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / DCC / dimethylformamide / 1.) 70 min, 0 deg C, 2.) 40 deg C, overnight

2: 1.) NaHCO₃, 2.) HCl / H₂O; dioxane / 1.) 15 min, ice-cooled, 2.) room temperature, overnight

With hydrogenchloride; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00330a022