77716-11-1

Basic information

• Product Name: 4-TERT-BUTOXYCARBONYLAMINO-1-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID
• Synonyms: 4-[(tert-Butoxycarbonyl)amino]-1-methyl-1H-pyrrole-2-carboxylic acid, 4-[(tert-Butoxycarbonyl)amino]-2-carboxy-1-methyl-1H-pyrrole;4-Amino-1-methyl-1H-pyrrole-2-carboxylicacid,4-BOCprotected97%;4-(Boc-amino)-1-methyl-1H-pyrrole-2-carboxylic acid≥ 97% (HPLC);BOC-4-AMINO-1-METHYLPYRROLE-2-CARBOXYLIC ACID;BOC-PY-OH;BOC-NH(4)-MEPYL-(2)-OH;BOC-NH(4)-MEPYRL-(2)-OH;4-(BOC-AMINO)-1-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID
• CAS NO: 77716-11-1
• Molecular Formula: C₁₁H₁₆N₂O₄
• Molecular Weight: 240.26
• Product Categories: Others;Peptide Synthesis;Unnatural Amino Acid Derivatives
• Mol File: 77716-11-1.mol
• Article Data: 12

Chemical Properties

• Melting Point: 156-160 °C (dec.)
• Boiling Point: 355 °C at 760 mmHg
• Flash Point: 168.5 °C
• Appearance: /
• Density: 1.21 g/cm³
• Vapor Pressure: 1.18E-05mmHg at 25°C
• Refractive Index: 1.536
• Storage Temp.: -15°C
• PKA: 4.66±0.41(Predicted)
• BRN: 4470648
• CAS DataBase Reference: 4-TERT-BUTOXYCARBONYLAMINO-1-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-TERT-BUTOXYCARBONYLAMINO-1-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID(77716-11-1)
• EPA Substance Registry System: 4-TERT-BUTOXYCARBONYLAMINO-1-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID(77716-11-1)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 77716-11-1(Hazardous Substances Data)

Usage

Chemical Properties

White crystalline powder

Uses

4-(Boc-amino)-1-methylpyrrole-2-carboxylic Acid is an unnatural amino acid for preparing heteroaromatic oligoamides for regulating gen expression in biotechnology.

InChI:InChI=1/C11H16N2O4/c1-11(2,3)17-10(16)12-7-5-8(9(14)15)13(4)6-7/h5-6H,1-4H3,(H,12,16)(H,14,15)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 13138-76-6 1-methyl-4-nitropyrrole-2-carboxylic acid methyl ester 
• 180258-45-1 methyl 4-amino-1-methyl-pyrrole-2-carboxylate hydrochloride 
• 2853-29-4 ethyl 1-methyl-4-nitro-1H-pyrrole-2-carboxylate 
• 13138-78-8 1-methyl-4-nitro-pyrrol-2-carboxylic acid 
• 72083-62-6 methyl 4-amino-1-methyl-1H-pyrrole-2-carboxylate 
• 37619-24-2 methyl N-methylpyrrole-2-carboxylate 
• 6973-60-0 1-Methyl-2-pyrrolecarboxylic acid 
• 184643-69-4 1-(4-bromo-1-methyl-1H-pyrrol-2-yl)-2,2,2-trichloroethan-1-one 
• 1196-90-3 4-bromo-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester 
• 21898-65-7 1-methyl-2-trichloroacetyl-1H-pyrrole 
• 96-54-8 N-Methylpyrrole 
• 126092-96-4 methyl 4-<<(tert-butyloxy)carbonyl>amino>-1-methyl-pyrrole-2-carboxylate 
• 45776-13-4 4-amino-1-methylpyrrole-2-carboxylic acid 

Downstream Products

• 126092-97-5 methyl 4-<<<4-<<(tert-butyloxy)carbonyl>amino>-1-methyl-pyrrol-2-yl>carbonyl>amino>-1-methyl-pyrrole-2-carboxylate 
• 195387-56-5 Boc-pyrrolyl-4-(oxymethyl)phenylacetic acid 
• 1186300-99-1 C₂₇H₃₂N₆O₄ 
• 1186300-98-0 C₂₁H₂₆N₄O₃ 
• 126093-00-3 methyl 4-<<<4-<<<4-<<(tert-butyloxy)carbonyl>amino>-1-methyl-pyrrol-2-yl>carbonyl>amino>-1-methyl-pyrrol-2-yl>carbonyl>amino>-1-methyl-pyrrole-2-carboxylate 
• 126092-99-7 methyl 4-(4-amino-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxylate 
• 1132797-92-2 C₃₀H₃₀N₆O₆ 
• 77716-15-5 benzyl 4-<<<4-<<(tert-butyloxy)carbonyl>amino>-1-methyl-pyrrol-2-yl>carbonyl>amino>-1-methyl-pyrrole-2-carboxylate 
• 500903-64-0 (5-chlorocarbonyl-1-methyl-1H-pyrrol-3-yl)-carbamic acid tert-butyl ester 
• 864076-01-7 ethyl 2-{4-[(4-tert-butoxycarbonylamino-1-methyl-1H-pyrrole-2-carbonyl)-amino]-phenyl}-thiazole-4-carboxylate 
• 864672-93-5 4-({4-[(4-tert-butoxycarbonylamino-1-methyl-1H-pyrrole-2-carbonyl)amino]-1-methyl-1H-imidazole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester 
• 292070-06-5 methyl 4-(4-(tert-butoxycarbonylamino)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-imidazole-2-carboxylate 
• 77727-43-6 N-Succinimidyl 4-<<<4-<<<4-(Formylamino)-1-methylpyrrol-2-yl>carbonyl>amino>-1-methylpyrrol-2-yl>carbonyl>amino>-1-methylpyrrole-2-carboxylate 

Relevant articles and documents

NOVEL BENZODIAZEPINE DERIVATIVES

The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and (II), in which the diazepine ring (B) is fused with a heterocyclic ring (CD), wherein the heterocyclic ring is bicyclic or a compound of formula (III), in which the diazepine ring (B) is fused with a heterocyclic ring (C), wherein the heterocyclic ring is monocyclic. The invention provides cytotoxic dimers of these compounds. The invention also provides conjugates of the monomers and the dimers. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. The invention further relates to methods of using the compounds or conjugates for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

2’-DEOXYGUANOSINE HYBRID COMPOUND CONTAINING PYRROLE AMIDE TETRAMER, METHOD OF PRODUCING THE SAME AND PRODUCTION INTERMEDIATE THEREFOR

It is intended to provide an MGB polyamide hybrid compound which has a function of recognizing a base sequence useful in gene therapy, is efficacious in synthesizing an oligomer and has a high stability. An MGB polyamide hybrid compound represented by the following formula (38) which is characterized by being a pyrrole amide tetramer prepared by introducing a 1-methylpyrrole-2-carbonyl group as a substitute for the N-terminal formyl group in the existing case.

Synthesis of distamycin a polyamides targeting G-quadruplex DNA

A number of amide-linked oligopyrroles based on distamycin molecules have been synthesized by solid-state methods, and their interactions with a human intramolecular G-quadruplex have been measured by a melting procedure. Several of these molecules show an enhanced ratio of quadruplex vs. duplex DNA binding compared to distamycin itself, including one with a 2,5-disubstituted pyrrole group. Quadruplex affinity increases with the number of pyrrole groups, and it is suggested that this is consistent with a mixed groove/G-quartet stacking binding mode. The Royal Society of Chemistry 2006.