Benzeneethanethioic acid, a-hydroxy-, S-phenyl ester

Base Information

• Chemical Name: Benzeneethanethioic acid, a-hydroxy-, S-phenyl ester
• CAS No.: 65544-99-2
• Molecular Formula: C14H12O2S
• Molecular Weight: 244.314
• Mol file: 65544-99-2.mol

Synonyms:

Chemical Property of Benzeneethanethioic acid, a-hydroxy-, S-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneethanethioic acid, a-hydroxy-, S-phenyl ester

There total 8 articles about Benzeneethanethioic acid, a-hydroxy-, S-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

S-phenyl 2-oxo-2-phenylethanethioate (94123-66-7) → S-phenyl 2-hydroxy-2-phenyl(thioethanoate) (65544-99-2)

Guidance literature:

With triethylsilane; trifluoroacetic acid; at 20 ℃; for 0.166667h; Reagent/catalyst; chemoselective reaction; Inert atmosphere;

DOI:10.1002/adsc.201900222

Reference yield: 33.0%

S-phenyl 2-iodo-2-phenyl(thioethanoate) (120346-79-4) → S-phenyl 2-phenylethanethioate (18245-74-4) + S-phenyl 2-hydroxy-2-phenyl(thioethanoate) (65544-99-2)

Guidance literature:

With magnesium iodide; In diethyl ether; for 96h; Ambient temperature;

DOI:10.1039/P19910003091

Reference yield:

bis(phenylthio)methane (3561-67-9) → S-phenyl 2-hydroxy-2-phenyl(thioethanoate) (65544-99-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 30percent aq. H₂O₂ / acetic acid / 1.33 h / Ambient temperature

2: potassium permanganate / acetone; H₂O / 1 h / Ambient temperature

3: 84 percent / potassium carbonate / propan-2-ol / 3 h / Heating

4: 96 percent / lithium tert-butyl hydroperoxide / tetrahydrofuran; toluene / 1.33 h / -78 °C

5: 80 percent Chromat_. / magnesium iodide / diethyl ether / 1 h / 0 °C

6: 33 percent / magnesium iodide / diethyl ether / 96 h / Ambient temperature

With potassium permanganate; lithium tert-butyl hydroperoxide; dihydrogen peroxide; potassium carbonate; magnesium iodide; In tetrahydrofuran; diethyl ether; water; acetic acid; isopropyl alcohol; acetone; toluene;

DOI:10.1039/P19910003091

upstream raw materials:

S-phenyl 2-iodo-2-phenyl(thioethanoate)

bis(phenylthio)methane

phenyl phenylthiomethyl sulfoxide

1-(phenylsulfanyl)methyl phenyl sulfone

Downstream raw materials:

S-phenyl 2-oxo-2-phenylethanethioate