94123-66-7

Upstream product

• 65544-99-2 S-phenyl 2-hydroxy-2-phenyl(thioethanoate) 
• 16222-10-9 1-phenyl-2-(phenylthio)ethanone 
• 611-73-4 Benzoylformic acid 
• 122-78-1 phenylacetaldehyde 
• 108-98-5 thiophenol 
• 98-86-2 acetophenone 
• 882-33-7 diphenyldisulfane 
• 6099-23-6 1-(phenylsulfinyl)acetophenone 
• 137524-63-1 2,2-Dichloro-1-phenyl-2-phenylsulfanyl-ethanone 

Downstream Products

• 139-66-2 diphenyl sulfide 
• 884-09-3 phenyl thiobenzoate 
• 65544-99-2 S-phenyl 2-hydroxy-2-phenyl(thioethanoate) 
• 55-21-0 benzamide 
• 614-22-2 1-benzoylurea 
• 5499-34-3 N-Benzoyl-N',N'-pentamethylen-harnstoff 
• 35337-84-9 N-methoxycarbonyl benzamide 
• 15206-55-0 methyl 2-oxo-2-phenylacetate 

Relevant academic research and scientific papers

Method for continuously preparing alpha-ketone thioester by using micro-channel reaction device

The invention provides a method for continuously preparing alpha-ketone thioester by using a micro-channel reaction device, the method comprises the following steps:taking phenylacetaldehyde and thiophenol as reaction raw materials, carrying out continuous reaction in the micro-channel reaction device in the presence of an initiator and a solvent, and carrying out oxidative coupling reaction to obtain alpha-ketone thioester III; the novel alpha-ketone thioester preparation method provided by the invention is efficient, safe and simple in process operation, mild in reaction condition and easy to amplify. The reaction process is shown as a reaction formula.

Non-Bonding 1,4-Sulphur-Oxygen Interaction Governs the Reactivity of α-Ketothioesters in Triphenylphosphine-Catalyzed Cyclization with Acetylenedicarboxylates

α-Ketothioesters undergo triphenylphosphine (PPh3)-catalyzed cyclization with acetylenedicarboxylate esters smoothly, in contrast to α-ketooxoesters which require more drastic conditions with the limited substrate scope. The reaction works well

Metal-Free Oxidative Thioesterification of Methyl Ketones with Thiols/Disulfides for the Synthesis of α-Ketothioesters

A direct Csp3-H bond oxidative thioesterification of methyl ketones with aromatic thiols/disulfides promoted by TBAI/K2S2O8 has been developed. The reaction provides successfully a simple and efficient method for the synthesis of functionalized α-ketothioesters of aromatic thiols. This practical methodology exhibits readily available starting materials, large-scale applicability, synthetic application, and broad functional group tolerance. A possible mechanism for the transformation is proposed.

Asymmetrie aerobic oxidation of α-hydroxy acid derivatives by C 4-symmetric, vanadate-centered, tetrakisvanadyl(V) clusters derived from N-salicylidene-α-aminocarboxylates

(Chemical Equation Presented) A series of chiral vanadyl(V) methoxides bearing 3-t-butyl-5-substituted N-salicylene-L-valinate and L-t-leucinate as chiral auxiliaries has been prepared. In all cases except the 3,5-di-t-butyl analogue, they exist as monomers both in solution and in the single crystal state. In the case of the 3,5-di-t-butyl analogue, the architectural nature of the vanadyl(V) complex highly depends on the base used during the complex formation event. A pentanuclear C4-symmetric complex was formed when potassium salts were employed instead of the corresponding sodium salts. A central vanadate(V) unit serves to grip four identical chiral monomelic vanadyl(V) units together, by which a potassium ion sits on top of the four flanking units through carbonyl coordinations and serves to hold the whole cluster by cooperation with the central vanadate(V) unit. In comparison with the corresponding monomelic vanadyl(V) methoxide complex, the cluster complex was utilized to facilitate the asymmetric aerobic oxidations of various racemic α-hydroxyesters, -amides, and -thioesters with excellent selectivity factors (krel 40 to >500).

Dihalogenation of β-ketosulfides. Synthesis of α-keto methyl esters and α-keto S-phenyl thioesters

α-Keto esters and α-keto S-phenyl thioesters are synthesized from β-keto sulfides by dihalogenation with sulfuryl chloride followed by solvolysis with methanol and acetone/water respectively.

PUMMERER REARRANGEMENT PROMOTED BY POLYPHOSPHORIC ACID TRIMETHYLSILYL ESTER (PPSE)

It was found that PPSE catalyzed Pummerer rearrangement of various types of sulfoxides.When α-(phenylsulfinyl)acetophenone was used as sulfoxide, unusual product, phenyl phenylthioglyoxylate was isolated.The reaction seems to proceed via phosphorylation of oxygen of sulfoxides.