Cropropamide

Base Information

• Chemical Name: Cropropamide
• CAS No.: 633-47-6
• Molecular Formula: C13H24 N2 O2
• Molecular Weight: 240.346
• European Community (EC) Number: 211-193-8
• UNII: W8TYE9V9BX
• DSSTox Substance ID: DTXSID601016511
• Nikkaji Number: J6.903E
• Wikidata: Q27292467
• NCI Thesaurus Code: C81396
• ChEMBL ID: CHEMBL2106529
• Mol file: 633-47-6.mol

Synonyms:cropropamide;cropropamide, (E)-isomer

Chemical Property of Cropropamide

Chemical Property:

• Vapor Pressure: 3.12E-06mmHg at 25°C
• Boiling Point: 388.2°C at 760 mmHg
• PKA: -0.74±0.70(Predicted)
• Flash Point: 161.8°C
• PSA: 40.62000
• Density: 0.977g/cm³
• LogP: 1.66790
• Storage Temp.: Amber Vial, Refrigerator
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Soluble)
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 240.183778013
• Heavy Atom Count: 17
• Complexity: 285

Purity/Quality:

99% ^*data from raw suppliers

Cropropamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCN(C(CC)C(=O)N(C)C)C(=O)C=CC
• Isomeric SMILES: CCCN(C(CC)C(=O)N(C)C)C(=O)/C=C/C
• Uses: Cropropamide, is the main component of the drug Prethcamide, which is a respiratory stimulant.
• Therapeutic Function: Respiratory stimulant

Technology Process of Cropropamide

There total 2 articles about Cropropamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

DL-2-propylamino-butyric acid dimethylamide (84803-62-3) + crotonyl chloride (10487-71-5) → cropropamide (633-47-6,3544-46-5)

Guidance literature:

With diethyl ether;

Reference yield:

→ cropropamide (633-47-6,3544-46-5)

Guidance literature:

With sodium amide; xylene; anschliessendes Erhitzen mit DL-2-Brom-buttersaeure-dimethylamid;

upstream raw materials:

DL-2-propylamino-butyric acid dimethylamide

crotonyl chloride