Phenyl-(4-propoxyphenyl)methanone

Base Information

• Chemical Name: Phenyl-(4-propoxyphenyl)methanone
• CAS No.: 65565-59-5
• Molecular Formula: C16H16O2
• Molecular Weight: 240.302
• DSSTox Substance ID: DTXSID00392311
• Wikidata: Q82190428
• Mol file: 65565-59-5.mol

Synonyms:Phenyl-(4-propoxyphenyl)methanone;65565-59-5;Methanone, phenyl(4-propoxyphenyl)-;SCHEMBL50488;DTXSID00392311;AKOS008715959;A1-05778

Chemical Property of Phenyl-(4-propoxyphenyl)methanone

Chemical Property:

• XLogP3: 4.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 240.115029749
• Heavy Atom Count: 18
• Complexity: 248

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCOC1=CC=C(C=C1)C(=O)C2=CC=CC=C2

Technology Process of Phenyl-(4-propoxyphenyl)methanone

There total 3 articles about Phenyl-(4-propoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

propan-1-ol (71-23-8) + 4-fluorobenzophenone (345-83-5) → 4-propoxy-benzophenone (65565-59-5)

Guidance literature:

propan-1-ol; With N-benzyl-trimethylammonium hydroxide; for 0.166667h; Neat (no solvent);

4-fluorobenzophenone; at 50 ℃; for 0.75h; Neat (no solvent);

DOI:10.1080/00397910903219518

Reference yield: 79.0%

propyl bromide (106-94-5) + 4-Hydroxybenzophenone (1137-42-4) → 4-propoxy-benzophenone (65565-59-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 5h; Reflux; Inert atmosphere;

Reference yield:

propoxybenzene (622-85-5) + benzoyl chloride (98-88-4) → 4-propoxy-benzophenone (65565-59-5)

Guidance literature:

With carbon disulfide; aluminium trichloride;

upstream raw materials:

propoxybenzene

benzoyl chloride

propan-1-ol

4-fluorobenzophenone