Phosphoric acid, 4-chloro-2-methylphenyl dimethyl ester

Base Information

• Chemical Name: Phosphoric acid, 4-chloro-2-methylphenyl dimethyl ester
• CAS No.: 65659-05-4
• Molecular Formula: C₉H₁₂ClO₄P
• Molecular Weight: 250.619
• Mol file: 65659-05-4.mol

Synonyms:

Chemical Property of Phosphoric acid, 4-chloro-2-methylphenyl dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid, 4-chloro-2-methylphenyl dimethyl ester

There total 5 articles about Phosphoric acid, 4-chloro-2-methylphenyl dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + C14H14ClO4P → 5-chloro-3-methyl[1,1'-biphenyl]-2-yl dimethyl phosphate (1431299-70-5) + 4-chloro-2-methylphenyl dimethyl phosphate (65659-05-4)

Guidance literature:

With diazomethyl-trimethyl-silane; In hexane; at 20 ℃; for 0.5h;

DOI:10.1021/ol400732q

Reference yield:

C7H6Cl3O2P (105053-58-5) → 5-chloro-3-methyl[1,1'-biphenyl]-2-yl dimethyl phosphate (1431299-70-5) + 4-chloro-2-methylphenyl dimethyl phosphate (65659-05-4)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / diethyl ether / Cooling with ice

2: sodium hydroxide / dichloromethane; water / 20 °C

3: palladium(II) trifluoroacetate / 1,2-dichloro-ethane / 15 h / 80 °C

4: diazomethyl-trimethyl-silane / hexane / 0.5 h / 20 °C

With pyridine; palladium(II) trifluoroacetate; sodium hydroxide; diazomethyl-trimethyl-silane; In diethyl ether; hexane; dichloromethane; water; 1,2-dichloro-ethane;

DOI:10.1021/ol400732q

Reference yield:

2-methyl-4-chlorophenol (1570-64-5) → 5-chloro-3-methyl[1,1'-biphenyl]-2-yl dimethyl phosphate (1431299-70-5) + 4-chloro-2-methylphenyl dimethyl phosphate (65659-05-4)

Guidance literature:

Multi-step reaction with 5 steps

1: trichlorophosphate; pyridine / benzene / 1 h / Reflux

2: pyridine / diethyl ether / Cooling with ice

3: sodium hydroxide / dichloromethane; water / 20 °C

4: palladium(II) trifluoroacetate / 1,2-dichloro-ethane / 15 h / 80 °C

5: diazomethyl-trimethyl-silane / hexane / 0.5 h / 20 °C

With pyridine; palladium(II) trifluoroacetate; sodium hydroxide; trichlorophosphate; diazomethyl-trimethyl-silane; In diethyl ether; hexane; dichloromethane; water; 1,2-dichloro-ethane; benzene;

DOI:10.1021/ol400732q

upstream raw materials:

methanol

4-chloro-2-methylphenyl methyl hydrogen phosphate

2-methyl-4-chlorophenol

C₇H₆Cl₃O₂P

Refernces