2(1H)-Quinolinone,1-(phenylmethyl)-(9CI)

Base Information

• Chemical Name: 2(1H)-Quinolinone,1-(phenylmethyl)-(9CI)
• CAS No.: 65745-74-6
• Molecular Formula: C16H13NO
• Molecular Weight: 235.285
• Mol file: 65745-74-6.mol

Synonyms:1-Benzyl-1,2-dihydroquinoline-2-one;1-benzyl-1H-quinolin-2-one;1-Benzyl-1H-chinolin-2-on;N-benzyl-2-quinolone;

Chemical Property of 2(1H)-Quinolinone,1-(phenylmethyl)-(9CI)

Chemical Property:

• PSA: 22.00000
• LogP: 3.04980

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2(1H)-Quinolinone,1-(phenylmethyl)-(9CI)

There total 18 articles about 2(1H)-Quinolinone,1-(phenylmethyl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C18H17NO (1035669-83-0) → 1-benzylquinolin-2(1H)-one (65745-74-6)

Guidance literature:

tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 40 ℃;

DOI:10.1016/j.tetlet.2008.03.144

Reference yield: 83.0%

1-benzylquinolin-1-ium tetrafluoroborate → 1-benzylquinolin-2(1H)-one (65745-74-6)

Guidance literature:

With potassium tert-butylate; Dimethyl phosphite; In acetonitrile; at 0 - 35 ℃; Sealed tube;

DOI:10.1039/c8ob01032c

Reference yield: 81.0%

benzyl bromide (100-39-0) + 2-hydroxyquinoline (59-31-4) → 1-benzylquinolin-2(1H)-one (65745-74-6)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; In neat (no solvent); at 130 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.joc.8b00787

upstream raw materials:

2-(benzyloxy)quinoline

benzyl bromide

1-benzylquinolin-1-ium chloride

2-quinolone

Downstream raw materials:

1-benzyl-2(1H)-thioquinolone

2-[bis(acetyl)methylene]-1-benzyl-1,2-dihydroquinoline

2-[acetyl(methoxycarbonyl)methylene]-1-benzyl-1,2-dihydroquinoline

1-benzyl-1,2-dihydro-2-[bis(methoxycarbonyl)methylene]quinoline