N-(4-Chlorophenyl)-2-(hydroxyimino)acetamide

Base Information

• Chemical Name: N-(4-Chlorophenyl)-2-(hydroxyimino)acetamide
• CAS No.: 65798-06-3
• Molecular Formula: C₈H₇ClN₂O₂
• Molecular Weight: 198.609
• European Community (EC) Number: 241-186-5
• DSSTox Substance ID: DTXSID501216209
• Mol file: 65798-06-3.mol

Synonyms:N-(4-Chlorophenyl)-2-(hydroxyimino)acetamide;17122-56-4;SCHEMBL10212303;HMS546F17;HPTQNIZSFRLFIU-BJMVGYQFSA-N;DTXSID501216209;STK449732;AKOS003239131;65798-06-3;N-(3-Chlorophenyl)-2-hydroxyimino-acetamide;(2E)-N-(4-Chlorophenyl)-2-(hydroxyimino)ethanamide;(2E)-N-(4-Chlorophenyl)-2-(hydroxyimino)ethanamide #;Acetamide, N-(4-chlorophenyl)-2-(hydroxyimino)-, (E)-

Chemical Property of N-(4-Chlorophenyl)-2-(hydroxyimino)acetamide

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 198.0196052
• Heavy Atom Count: 13
• Complexity: 200

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1NC(=O)C=NO)Cl
• Isomeric SMILES: C1=CC(=CC=C1NC(=O)/C=N/O)Cl

Technology Process of N-(4-Chlorophenyl)-2-(hydroxyimino)acetamide

There total 6 articles about N-(4-Chlorophenyl)-2-(hydroxyimino)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-chloro-aniline (106-47-8) + chloral (75-87-6) → N-(4-chlorophenyl)-2-(hydroxyimino)ethanamide (65798-06-3,17122-56-4)

Guidance literature:

With hydroxyammonium sulfate; sodium sulfate; In water; at 70 - 80 ℃; for 3h;

DOI:10.1016/S0040-4039(97)00140-8

Reference yield: 80.9%

→ N-(4-chlorophenyl)-2-(hydroxyimino)ethanamide (65798-06-3,17122-56-4)

Guidance literature:

With hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate; In water; at 65 ℃; for 2h;

Reference yield: 80.0%

chloral hydrate (302-17-0) + 4-chloro-aniline (106-47-8) → N-(4-chlorophenyl)-2-(hydroxyimino)ethanamide (65798-06-3,17122-56-4)

Guidance literature:

With hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate; In water; at 20 ℃; for 3h; Reflux;

upstream raw materials:

chloral hydrate

4-chloro-aniline

chloral

p-chloroaniline hydrochloride

Downstream raw materials:

5-chloroindole 2,3-dione

(4-chloro-phenyl)-oxalamide

5-chloro-1-(p-fluorobenzyl)indoline-2,3-dione

1-benzyl-5-chloroisatin