1-Butanone, 1-(3,4-dichlorophenyl)-

Base Information

• Chemical Name: 1-Butanone, 1-(3,4-dichlorophenyl)-
• CAS No.: 6582-45-2
• Molecular Formula: C10H10Cl2O
• Molecular Weight: 217.095
• Mol file: 6582-45-2.mol

Synonyms:3,4-dichlorobutyrophenone;1-(3,4-Dichlor-phenyl)-butan-1-on;3',4'-dichlorobutyrophenone;3.4-Dichlor-butyrophenon;1-(3,4-dichloro-phenyl)-butan-1-one;Propyl-(3.4-dichlor-phenyl)-keton;

Chemical Property of 1-Butanone, 1-(3,4-dichlorophenyl)-

Chemical Property:

• PSA: 17.07000
• LogP: 3.97620

Purity/Quality:

98% ^*data from raw suppliers

1-(3,4-dichlorophenyl)butan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Butanone, 1-(3,4-dichlorophenyl)-

There total 5 articles about 1-Butanone, 1-(3,4-dichlorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-chloro-benzonitrile (766-84-7) + 1-propylmagnesium chloride (2234-82-4) → 1-(3,4-dichlorophenyl)butan-1-one (6582-45-2)

Guidance literature:

3-chloro-benzonitrile; 1-propylmagnesium chloride; In tetrahydrofuran; at 0 - 20 ℃; for 144h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; at 0 ℃;

With sodium hydrogencarbonate; In tetrahydrofuran; water;

Reference yield: 83.0%

3,4-dichloro-benzonitrile (6574-99-8) + 1-propylmagnesium chloride (2234-82-4) → 1-(3,4-dichlorophenyl)butan-1-one (6582-45-2)

Guidance literature:

3,4-dichloro-benzonitrile; 1-propylmagnesium chloride; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃;

DOI:10.1021/jm901189z

Reference yield: 68.0%

2-bromoprop-1-ene (557-93-7) + 3,4-dichlorobenzaldehyde (6287-38-3) → 1-(3,4-dichlorophenyl)butan-1-one (6582-45-2)

Guidance literature:

With acetylacetonatodicarbonylrhodium(l); potassium formate; potassium carbonate; triphenylphosphine; In 1,2-dimethoxyethane; at 130 ℃; for 16h; Inert atmosphere; Sealed tube;

DOI:10.1021/jacs.9b03113

upstream raw materials:

3,4-dichloro-benzonitrile

1-propylmagnesium chloride

3-chloro-benzonitrile

2-bromoprop-1-ene

Downstream raw materials:

(+/-)-1-Isopropylamino-1-<3.4-dichlor-benzoyl>-propan

2-bromo-1-(3,4-dichlorophenyl)butan-1-one

α-<3,4-Dichlor-phenyl>-n-butylamin

{[1-(3,4-dichloro-phenyl)-butyl]-formyl-amino}-acetic acid methyl ester

Refernces

• 1、 -. "MONOAM1NE REUPTAKE INHIBITORS". Page/Page column 60. . Retrieved 2010/11/04.
• 2、 Meltzer, Peter C.,Butler, David,Deschamps, Jeffrey R.,Madras, Bertha K.. "1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (pyrovalerone) analogues: A promising class of monoamine uptake inhibitors". . p. 1420 - 1432. Retrieved 2007/10/03.