Desmethyl Piroxicam (Piroxicam Impurity B)

Base Information

• Chemical Name: Desmethyl Piroxicam (Piroxicam Impurity B)
• CAS No.: 65897-46-3
• Molecular Formula: C14H11N3O4S
• Molecular Weight: 317.325
• Mol file: 65897-46-3.mol

Synonyms:Piroxicam Impurity B;Desmethyl piroxicam;

Chemical Property of Desmethyl Piroxicam (Piroxicam Impurity B)

Chemical Property:

• Melting Point: 224℃ (decomposition)
• PKA: 4.50±1.00(Predicted)
• PSA: 120.26000
• Density: 1.611g/cm3
• LogP: 3.29790

Purity/Quality:

99%+, ^*data from raw suppliers

DesmethylPiroxicam(PiroxicamImpurityB) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Piroxicam impurity B.

Technology Process of Desmethyl Piroxicam (Piroxicam Impurity B)

There total 7 articles about Desmethyl Piroxicam (Piroxicam Impurity B) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

3-Oxo-1,2-benzoisothiazoline-2acetamide 1,1-Dioxide (66366-28-7) → 0-benzoic acid (86048-64-8) + pyroxicam (65897-46-3)

Guidance literature:

With sodium isopropylate; In isopropyl alcohol; at 140 ℃; for 0.666667h;

DOI:10.1002/jhet.5570200133

Reference yield:

saccharin (81-07-2) → pyroxicam (65897-46-3)

Guidance literature:

With sodium methylate; In dimethyl sulfoxide;

Reference yield:

2-[(Pyridin-2-ylcarbamoylmethyl)-sulfamoyl]-benzoic acid methyl ester (86048-60-4) → pyroxicam (65897-46-3)

Guidance literature:

With sodium isopropylate; In isopropyl alcohol; at 140 ℃;

DOI:10.1002/jhet.5570200133

upstream raw materials:

3-Oxo-1,2-benzoisothiazoline-2acetamide 1,1-Dioxide

2-[(Pyridin-2-ylcarbamoylmethyl)-sulfamoyl]-benzoic acid methyl ester

2-aminopyridine

2-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)acetic acid

Downstream raw materials:

Piroxicam

Refernces

• 1、 Perillo,Schapira,Lamdan. "3-Oxo-1,2-benzoisothiazoline-2-acetic acid 1,1-dioxide derivatives. II. Reaction of amides with alkoxides". . p. 155 - 160. Retrieved 2007/10/02.