Saccharin

Base Information Edit

Chemical Name:Saccharin
CAS No.:81-07-2
Deprecated CAS:126987-83-5,474-91-9,61255-27-4,890126-34-8,474-91-9,61255-27-4,890126-34-8
Molecular Formula:C7H5NO3S
Molecular Weight:183.188
Hs Code.:29251100
European Community (EC) Number:201-321-0,228-971-8
NSC Number:757878,5349
UN Number:3077
UNII:FST467XS7D
DSSTox Substance ID:DTXSID5021251
Nikkaji Number:J747.663I,J3.855E
Wikipedia:Saccharin
Wikidata:Q191381
NCI Thesaurus Code:C76515
RXCUI:9509
Pharos Ligand ID:VR72KS9NK6KQ
Metabolomics Workbench ID:44013
ChEMBL ID:CHEMBL310671
Mol file:81-07-2.mol

Synonyms:Calcium, Saccharin;Saccharin;Saccharin Calcium;Saccharin Sodium

Suppliers and Price of Saccharin

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Saccharin
10g
$ 75.00

TCI Chemical
o-Sulfobenzimide >99.0%(HPLC)(T)
500g
$ 93.00

TCI Chemical
o-Sulfobenzimide >99.0%(HPLC)(T)
25g
$ 17.00

Sigma-Aldrich
Saccharin Saccharin for synthesis. CAS 81-07-2, molar mass 183.18 g/mol., for synthesis
8201280250
$ 55.70

Sigma-Aldrich
Saccharin ≥98%
250g
$ 53.70

Sigma-Aldrich
Saccharin for synthesis
250 g
$ 53.37

Sigma-Aldrich
Mettler-Toledo Calibration substance ME 51143091, Saccharin traceable to primary standards (LGC)
5g
$ 77.60

Sigma-Aldrich
Saccharin ≥98%
500g
$ 76.40

Sigma-Aldrich
Saccharin ≥99%
1g
$ 36.30

Sigma-Aldrich
Saccharin Pharmaceutical Secondary Standard; Certified Reference Material
1g
$ 72.80

Total 157 raw suppliers

Chemical Property of Saccharin Edit

Chemical Property:

Appearance/Colour:white crystalline solid
Vapor Pressure:0Pa at 25℃
Melting Point:226-229 °C(lit.)
Refractive Index:1.5500 (estimate)
Boiling Point:subl
PKA:11.68(at 18℃)
PSA：71.62000
Density:1.557 g/cm³
LogP:1.52830
Storage Temp.:Refrigerator
Solubility.:acetone: soluble1g in 12mL(lit.)
Water Solubility.:3.3 g/L (20 ºC)
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:182.99901420
Heavy Atom Count:12
Complexity:303

Purity/Quality:

99% ^*data from raw suppliers

Saccharin ^*data from reagent suppliers

Safty Information:

Pictogram(s): R40:Possible risks of irreversible effects.;
Hazard Codes: Xn:Harmful;
Statements: 40-62-63-68
Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Chemical Classes:Other Uses -> Food Additives
Canonical SMILES:C1=CC=C2C(=C1)C(=O)NS2(=O)=O
Recent ClinicalTrials:Pretympanoplasty Assessment of Patency and Mucociliary Function of Eustachian Tube
Description Saccharin is an organic compound that is normally used as a non-nutritive sweetening agent. Also known as ortho-sulfobenzoic acid imide, saccharin occurs in the form of various salts, mainly calcium and sodium.
Uses Saccharin is a non-nutritive synthetic sweetener which is 300–400 times sweeter than sucrose. it is nonhygroscopic and has a bitter aftertaste and a stability problem in cooked, canned, or baked goods. it is slightly soluble in water with a solubility of 10 g in 100 g of water at 25°c, but the solubility improves in boiling water. as sodium saccharin, there are two forms: 1,2-benzisothiazolin-3-one- 1,1-dioxide, sodium salt dihydrate, with a solubility of 1 g in 1.2 ml of water; and 1,2-benzisothiazolin-3-one-1,1-dioxide, sodium salt. calcium saccharin (chemical name: 1,2-benzisothiazolin-3-one-1, 1-dioxide, calcium salt) is used where low sodium content and reduced after-taste are required. it is used in low-calorie foods such as jam, beverages, and desserts. it is also termed sodium benzosulfimide. It is a non-nutritive sweetener; pharmaceutic aid (flavor). Saccharin was formerly listed as reasonably anticipated to be a human carcinogen; delisted because the cancer data are not sufficient to meet the current criteria for this listing. Usually used in high performance liquid chromatographic method for the simultaneous separation and determination of acesulfame potassium, saccharine and aspartame;and also used in sweet preference test of rats.

Technology Process of Saccharin

There total 140 articles about Saccharin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 132636-65-8
3-(4-nitro-phenoxy)-benz[d]isothiazole-1,1-dioxide

: 62-53-3
aniline

: 81-07-2
saccharin

Guidance literature:: With sodium hypophosphite; palladium on activated charcoal; In water; benzene; for 0.25h; Heating;
DOI:10.1016/S0040-4039(00)97960-7

Reference yield: 98.0%

: 132636-70-5
4-(1,1-Dioxo-1H-1λ⁶-benzo[d]isothiazol-3-yloxy)-benzoic acid methyl ester

: 93-58-3,5705-52-2,80226-58-0
benzoic acid methyl ester

: 81-07-2
saccharin

Guidance literature:: With sodium hypophosphite; palladium on activated charcoal; In water; benzene; for 0.75h; Heating;
DOI:10.1016/S0040-4039(00)97960-7

Reference yield: 63.0%

: 132636-72-7
3-(4-Fluoro-phenoxy)-benzo[d]isothiazole 1,1-dioxide

: 462-06-6
fluorobenzene

: 81-07-2
saccharin

Guidance literature:: With sodium hypophosphite; palladium on activated charcoal; In water; toluene; for 7h; Heating;
DOI:10.1016/S0040-4039(00)97960-7