DIMETHYLCARBAMOYLMETHYL-METHYL-CARBAMIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: DIMETHYLCARBAMOYLMETHYL-METHYL-CARBAMIC ACID TERT-BUTYL ESTER
• CAS No.: 65918-90-3
• Molecular Formula: C10H20N2O3
• Molecular Weight: 216.27700
• Mol file: 65918-90-3.mol

Synonyms:N-tertiobutoxycarbonylsarcosine N',N'-dimethylacetamide;DIMETHYLCARBAMOYLMETHYL-METHYL-CARBAMIC ACID TERT-BUTYL ESTER;Boc-Sar-N(CH3)2;

Chemical Property of DIMETHYLCARBAMOYLMETHYL-METHYL-CARBAMIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Boiling Point: 295.09oC at 760 mmHg
• Flash Point: 132.266oC
• PSA: 49.85000
• Density: 1.036g/cm3
• LogP: 0.94150

Purity/Quality:

97% ^*data from raw suppliers

DIMETHYLCARBAMOYLMETHYL-METHYL-CARBAMIC ACID TERT-BUTYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DIMETHYLCARBAMOYLMETHYL-METHYL-CARBAMIC ACID TERT-BUTYL ESTER

There total 2 articles about DIMETHYLCARBAMOYLMETHYL-METHYL-CARBAMIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N-(tert-butoxycarbonyl)sarcosine (13734-36-6) + dimethyl amine (124-40-3) → tert-butyl (2-(dimethylamino)-2-oxoethyl)(methyl)carbamate (65918-90-3)

Guidance literature:

N-(tert-butoxycarbonyl)sarcosine; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

dimethyl amine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1002/anie.201915744

Reference yield:

N-(tert-butyloxycarbonyl) azide (1070-19-5) → tert-butyl (2-(dimethylamino)-2-oxoethyl)(methyl)carbamate (65918-90-3)

Guidance literature:

Multi-step reaction with 2 steps

2: (i) ClCO₂iBu, (ii) /BRN= 605257/

Reference yield:

tert-butyl (2-(dimethylamino)-2-oxoethyl)(methyl)carbamate (65918-90-3) → sarcosine dimethylamide (1857-20-1)

Guidance literature:

With hydrogenchloride; In methanol;

upstream raw materials:

N-(tert-butoxycarbonyl)sarcosine

dimethyl amine

N-(tert-butyloxycarbonyl) azide

Downstream raw materials:

sarcosine dimethylamide

Refernces

• 1、 Asbury, John B.,Hoelzel, Conner A.,Hu, Hang,Jung, Kwan Ho,Karim, Basel A.,Li, Xiaosong,Liu, Yu,Munson, Kyle T.,Wolstenholme, Charles H.,Yennawar, Hemant P.,Zhang, Han,Zhang, Xin. "A General Strategy to Enhance Donor-Acceptor Molecules Using Solvent-Excluding Substituents". supporting information. p. 4785 - 4792. Retrieved 2020/02/11.