(R)-alpha-Hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid

Base Information

Chemical Name:(R)-alpha-Hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid
CAS No.:28875-92-5
Molecular Formula:C₁₀H₁₄N₂O₄
Molecular Weight:226.232
Hs Code.:
Nikkaji Number:J2.205.974B
ChEMBL ID:CHEMBL1417392
Mol file:28875-92-5.mol

Synonyms:28875-92-5;R-(+)-Carbidopa;(2R)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid;S-(-)-Carbidopa;(R)-alpha-Hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid;(S)-carbidopa;MK 486;Lopac-C-126;SCHEMBL8407333;CHEMBL1417392;HMS3261M05;Tox21_500382;Benzenepropanoic acid, alpha-hydrazino-3,4-dihydroxy-alpha-methyl-, (R)-;CCG-221686;LP00382;SDCCGSBI-0633707.P001;NCGC00015185-01;NCGC00186002-01;NCGC00186002-02;NCGC00261067-01;(R)-3-(3,4-Dihydroxyphenyl)-2-hydrazineyl-2-methylpropanoic acid;alpha-Hydrazino-3,4-dihydroxy-alpha-methyl-benzenepropanoic Acid;D-alpha-hydrazino-3,4-dihydroxy-alpha-methyl-hydrocinnamic Acid

Suppliers and Price of (R)-alpha-Hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
R-(+)-Carbidopa
10mg
$ 1455.00

TRC
R-(+)-Carbidopa
1mg
$ 185.00

Medical Isotopes, Inc.
R-(+)-Carbidopa
5 mg
$ 650.00

Biosynth Carbosynth
R-(+)-Carbidopa
5 mg
$ 500.00

Biosynth Carbosynth
R-(+)-Carbidopa
2 mg
$ 240.00

Biosynth Carbosynth
R-(+)-Carbidopa
1 mg
$ 150.00

Biosynth Carbosynth
R-(+)-Carbidopa
25 mg
$ 1800.00

Biosynth Carbosynth
R-(+)-Carbidopa
10 mg
$ 900.00

AK Scientific
(R)-alpha-Hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoicacid
10mg
$ 1265.00

Total 4 raw suppliers

Chemical Property of (R)-alpha-Hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid

Chemical Property:

Boiling Point:528.7±50.0 °C(Predicted)
PKA:3.40±0.14(Predicted)
PSA：115.81000
Density:1.420±0.06 g/cm3(Predicted)
LogP:1.03810
Storage Temp.:Hygroscopic, Refrigerator, under inert atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
XLogP3:-2.2
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:226.09535693
Heavy Atom Count:16
Complexity:261

Purity/Quality:

99% ^*data from raw suppliers

R-(+)-Carbidopa ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CC1=CC(=C(C=C1)O)O)(C(=O)O)NN
Isomeric SMILES:C[C@@](CC1=CC(=C(C=C1)O)O)(C(=O)O)NN
Uses R-(+)-Carbidopa is an inhibitor of DOPA decarboxylase, which plays a significant role in the prevention of the conversion of L-DOPA (D533751) to dopamine (D533780). Studies has also indicated the inhibitory effects of towards L-DOPA in human liver prepns and as well as 5-hydroxytryptophan (H975700).

Technology Process of (R)-alpha-Hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid

There total 9 articles about (R)-alpha-Hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1426847-83-7
(+)-2-[(1S)-1-(3,4-dimethoxybenzoyl)-2-methoxy-1-methyl-2-oxoethyl]hydrazinecarboxylic acid benzyl ester

: 302-53-4,14585-65-0,28860-95-9,28875-92-5,31823-41-3
S(-)-carbidopa

Guidance literature:: (+)-2-[(1S)-1-(3,4-dimethoxybenzoyl)-2-methoxy-1-methyl-2-oxoethyl]hydrazinecarboxylic acid benzyl ester; With boron tribromide; In dichloromethane; at -78 - 23 ℃; for 24h; Inert atmosphere;

With diethylamine; In isopropyl alcohol; enantioselective reaction;
DOI:10.1016/j.tet.2017.08.015

Reference yield: 87.0%

: C₁₄H₂₀N₂O₄

: 302-53-4,14585-65-0,28860-95-9,28875-92-5,31823-41-3
S(-)-carbidopa

Guidance literature:: With hydrogenchloride; In water; at 95 ℃; for 4h;

Reference yield: 87.0%

: 934371-48-9
(+)-(L)-2-(N'-cyclohexylidenehydrazino)-3-(3,4-dihydroxyphenyl)-2-methyl propionic acid methyl ester

: 302-53-4,14585-65-0,28860-95-9,28875-92-5,31823-41-3
S(-)-carbidopa

Guidance literature:: (+)-(L)-2-(N'-cyclohexylidenehydrazino)-3-(3,4-dihydroxyphenyl)-2-methyl propionic acid methyl ester; With hydrogenchloride; In water;

With ammonia; In water; pH=3.5;