Ethyl (Z)-alpha-(hydroxyimino)-2-(tritylamino)thiazol-4-acetate hydrochloride

Base Information

• Chemical Name: Ethyl (Z)-alpha-(hydroxyimino)-2-(tritylamino)thiazol-4-acetate hydrochloride
• CAS No.: 66339-00-2
• Molecular Formula: C26H24ClN3O3S
• Molecular Weight: 494.014
• European Community (EC) Number: 266-321-5
• Mol file: 66339-00-2.mol

Synonyms:66339-00-2;Ethyl (Z)-alpha-(hydroxyimino)-2-(tritylamino)thiazol-4-acetate hydrochloride;EINECS 266-321-5;ethyl (2Z)-2-hydroxyimino-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetate;hydrochloride;Ethyl 2-(hydroxyimino)-2-(2-(tritylamino)thiazol-4-yl)acetate hydrochloride;(Z)-Ethyl 2-(hydroxyimino)-2-(2-(tritylamino)thiazol-4-yl)acetate hydrochloride;C26H23N3O3S.ClH;SCHEMBL2558723;AKOS024370947;C26-H23-N3-O3-S.Cl-H;(Z)-Ethyl2-(hydroxyimino)-2-(2-(tritylamino)thiazol-4-yl)acetatehydrochloride;Ethyl(Z)-alpha-(hydroxyimino)-2-(tritylamino)thiazol-4-acetate hydrochloride

Chemical Property of Ethyl (Z)-alpha-(hydroxyimino)-2-(tritylamino)thiazol-4-acetate hydrochloride

Chemical Property:

• Melting Point: 176-180oC (dec.)(lit.)
• Boiling Point: 649.7°Cat760mmHg
• Flash Point: 346.8°C
• PSA: 112.05000
• Density: g/cm³
• LogP: 6.16350
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 9
• Exact Mass: 493.1226905
• Heavy Atom Count: 34
• Complexity: 610

Purity/Quality:

99% ^*data from raw suppliers

(Z)-Ethyl2-(hydroxyimino)-2-(2-(tritylamino)thiazol-4-yl)acetatehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCOC(=O)C(=NO)C1=CSC(=N1)NC(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.Cl
• Isomeric SMILES: CCOC(=O)/C(=N\O)/C1=CSC(=N1)NC(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.Cl

Technology Process of Ethyl (Z)-alpha-(hydroxyimino)-2-(tritylamino)thiazol-4-acetate hydrochloride

There total 1 articles about Ethyl (Z)-alpha-(hydroxyimino)-2-(tritylamino)thiazol-4-acetate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trityl chloride (76-83-5) → ethyl (Z)-2-(2-triphenylmethylaminothiazol-4-yl)-2-(hydroxyimino)acetate hydrochloride (66339-00-2)

Guidance literature:

With triethylamine; In N-methyl-acetamide; (2S)-N-methyl-1-phenylpropan-2-amine hydrate;

Reference yield: 90.0%

tert-butyl bromoisobutyrate (23877-12-5) + ethyl (Z)-2-(2-triphenylmethylaminothiazol-4-yl)-2-(hydroxyimino)acetate hydrochloride (66339-00-2) → imino-2 Z (tritylamino-2 thiazolyl-4)-2 acetate d'ethyle (68672-65-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 1.5h; Ambient temperature;

Reference yield: 70.0%

ethyl bromoacetate (105-36-2) + ethyl (Z)-2-(2-triphenylmethylaminothiazol-4-yl)-2-(hydroxyimino)acetate hydrochloride (66339-00-2) → (ethoxy-2 oxo-2 ethoxy)-imino-2 Z (tritylamino-2 thiazolyl-4)-2 acetate d'ethyle (68672-60-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 1.5h; Ambient temperature;

upstream raw materials:

trityl chloride

Downstream raw materials:

imino-2 Z (tritylamino-2 thiazolyl-4)-2 acetate d'ethyle

(ethoxy-2 oxo-2 ethoxy)-imino-2 Z (tritylamino-2 thiazolyl-4)-2 acetate d'ethyle

(Z)-2-Hydroxyimino-2-(2-triphenylmethylaminothiazol-4-yl)-acetic acid

2-(2-triphenylmethylamino-4-thiazolyl)-2-[Z-(1-methoxy-1-methylethyl)oxyimino]acetic acid