2'-Chlorothymidine

Base Information

Chemical Name:2'-Chlorothymidine
CAS No.:54898-34-9
Molecular Formula:C10H13 Cl N2 O5
Molecular Weight:276.677
Hs Code.:
Nikkaji Number:J1.800.667G
Mol file:54898-34-9.mol

Synonyms:2'-chloro-2'-deoxythymidine;2'-chlorothymidine

Suppliers and Price of 2'-Chlorothymidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
1-((2R,3R,4R,5R)-3-Chloro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 97%
100mg
$ 396.00

Chemenu
1-((2R,3R,4R,5R)-3-chloro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 97%
100mg
$ 374.00

Biosynth Carbosynth
2’-Chloro-2’-deoxy-5-methyluridine
100 mg
$ 550.00

Biosynth Carbosynth
2’-Chloro-2’-deoxy-5-methyluridine
50 mg
$ 330.00

Biosynth Carbosynth
2’-Chloro-2’-deoxy-5-methyluridine
25 mg
$ 210.00

Biosynth Carbosynth
2’-Chloro-2’-deoxy-5-methyluridine
10 mg
$ 105.00

Biosynth Carbosynth
2’-Chloro-2’-deoxy-5-methyluridine
5 mg
$ 65.00

Total 9 raw suppliers

Chemical Property of 2'-Chlorothymidine

Chemical Property:

PSA：104.55000
Density:1.59g/cm³
LogP:-1.29700
XLogP3:-0.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:276.0512992
Heavy Atom Count:18
Complexity:413

Purity/Quality:

97% ^*data from raw suppliers

1-((2R,3R,4R,5R)-3-Chloro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)Cl
Isomeric SMILES:CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)Cl

Technology Process of 2'-Chlorothymidine

There total 1 articles about 2'-Chlorothymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.9%

: 22423-26-3
O-2,2'-cyclo-5-methyluridine

: 54898-34-9
2'-chlorothymidine

Guidance literature:: With hydrogenchloride; In N,N-dimethyl acetamide; at 60 ℃; for 5h;

Reference yield: 90.3%

: 54898-34-9
2'-chlorothymidine

: 50-89-5,28854-96-8,3545-96-8,50-88-4
thymidine

Guidance literature:: With hydrogen; nickel; In aq. phosphate buffer; at 40 ℃; for 8h; under 760.051 Torr; pH=7.2; Reagent/catalyst; Temperature; pH-value; Green chemistry;

Reference yield:

: 54898-34-9
2'-chlorothymidine

: 30516-87-1,399024-19-2
3'-azido-2',3'-deoxythymidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / dichloromethane / 40 °C

1.2: 10 - 15 °C

2.1: sodium acetate; 5%-palladium/activated carbon; hydrogen / methanol / 20 °C

3.1: potassium carbonate / acetonitrile / Reflux

4.1: sodium azide / N,N-dimethyl-formamide / 110 °C

5.1: sodium methylate / methanol / 1 h / 20 °C

With pyridine; sodium azide; 5%-palladium/activated carbon; hydrogen; sodium methylate; sodium acetate; potassium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;