2-(4-Methoxyphenyl)-3-pyridinamine

Base Information

• Chemical Name: 2-(4-Methoxyphenyl)-3-pyridinamine
• CAS No.: 663918-44-3
• Molecular Formula: C12H12N2O
• Molecular Weight: 200.24
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID90377298
• Nikkaji Number: J2.315.188J
• Wikidata: Q82166467
• Mol file: 663918-44-3.mol

Synonyms:2-(4-methoxyphenyl)-3-pyridinamine;2-(4-methoxyphenyl)pyridin-3-amine;663918-44-3;2-(4-Methoxy-phenyl)-pyridin-3-ylamine;SCHEMBL1551352;DTXSID90377298;MFCD06411622;2-(4-Methoxyphenyl)-3-aminopyridine;3-amino-2-(4-methoxyphenyl)pyridine;3-pyridinamine,2-(4-methoxyphenyl)-;AKOS005070717;CS-0322701;2-(4-methoxyphenyl)-3-pyridinamine, AldrichCPR;5Y-0701

Chemical Property of 2-(4-Methoxyphenyl)-3-pyridinamine

Chemical Property:

• Melting Point: 78～80℃
• Boiling Point: 374.3±32.0 °C(Predicted)
• PKA: 6.14±0.25(Predicted)
• PSA: 48.14000
• Density: 1.149±0.06 g/cm3(Predicted)
• LogP: 2.92060
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 200.094963011
• Heavy Atom Count: 15
• Complexity: 190

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-methoxyphenyl)-3-pyridinamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=C(C=CC=N2)N

Technology Process of 2-(4-Methoxyphenyl)-3-pyridinamine

There total 7 articles about 2-(4-Methoxyphenyl)-3-pyridinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-chloro-3-aminopyridine (6298-19-7) + 4-methoxyphenylboronic acid (5720-07-0) → 2-(4-methoxyphenyl)pyridine-3-amino (663918-44-3)

Guidance literature:

With potassium carbonate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In water; toluene; for 12h; Heating;

DOI:10.1021/ol060268g

Reference yield: 75.0%

→ 2-(4-methoxyphenyl)pyridine-3-amino (663918-44-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; toluene; at 80 ℃; for 8h; Inert atmosphere;

Reference yield:

2-(4-methoxyphenyl)-3-nitropyridine (182925-45-7) → 2-(4-methoxyphenyl)pyridine-3-amino (663918-44-3)

Guidance literature:

With hydrogen; platinum on carbon; In ethanol; at 20 ℃; for 4h;

upstream raw materials:

2-chloro-3-aminopyridine

4-methoxyphenylboronic acid

2-(4-methoxyphenyl)-3-nitropyridine

3-amino-2-bromopyridine

Downstream raw materials:

C₂₄H₂₁N₂O₂P

Refernces

• 1、 Zhang, Xumu,Chen, Gen-Qiang,Zheng, Long-Sheng,Wang, Fangyuan,Ye, Xiang-Yu. "Asymmetric hydrogenation of 2-aryl-3-phthalimidopyridinium salts: Synthesis of piperidine derivatives with two contiguous stereocenters". supporting information. p. 8882 - 8887. Retrieved 2020/12/02.
• 2、 Du, Shijie,Tian, Zaimin,Yang, Dongyan,Li, Xiuyun,Li, Hong,Jia, Changqing,Che, Chuanliang,Wang, Mian,Qin, Zhaohai. "Synthesis, antifungal activity and structure-activity relationships of novel 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid amides". . p. 8395 - 8408. Retrieved 2015/05/20.