2,2-dichloro-N-(naphthalen-1-yl)acetamide

Base Information

• Chemical Name: 2,2-dichloro-N-(naphthalen-1-yl)acetamide
• CAS No.: 1140-53-0
• Molecular Formula: C₁₂H₉Cl₂NO
• Molecular Weight: 254.116
• Mol file: 1140-53-0.mol

Synonyms:Acetamide,2,2-dichloro-N-1-naphthyl- (7CI,8CI); Dichloroacetyl-1-naphthylamide; NSC204130

Chemical Property of 2,2-dichloro-N-(naphthalen-1-yl)acetamide

Chemical Property:

• Vapor Pressure: 4.41E-08mmHg at 25°C
• Boiling Point: 444.1°Cat760mmHg
• Flash Point: 222.4°C
• Density: 1.413g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-dichloro-N-(naphthalen-1-yl)acetamide

There total 2 articles about 2,2-dichloro-N-(naphthalen-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

dichloromethane (75-09-2) + 1-Naphthyl isocyanate (86-84-0) → 2,2-dichloro-N-(1-naphthyl)acetamide (1140-53-0)

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine; methyllithium; lithium bromide; In tetrahydrofuran; at -78 ℃; for 1h; chemoselective reaction;

DOI:10.1055/s-0034-1379209

Reference yield: 85.0%

5,5-dichloro-meldrum’s acid + 1-amino-naphthalene (134-32-7) → 2,2-dichloro-N-(1-naphthyl)acetamide (1140-53-0)

Guidance literature:

In ethyl acetate; at 20 ℃; for 16h; Sealed tube;

DOI:10.1021/acs.orglett.1c00850

upstream raw materials:

dichloromethane

1-Naphthyl isocyanate

1-amino-naphthalene