4-(Pyridin-4-ylmethyl)phenol

Base Information

Chemical Name:4-(Pyridin-4-ylmethyl)phenol
CAS No.:66414-18-4
Molecular Formula:C12H11NO
Molecular Weight:185.225
Hs Code.:
European Community (EC) Number:815-925-2
DSSTox Substance ID:DTXSID901309860

Synonyms:4-(pyridin-4-ylmethyl)phenol;66414-18-4;Phenol, 4-(4-pyridinylmethyl)-;4-(4-pyridinylmethyl)Phenol;4-Pyridin-4-ylmethyl-phenol;SCHEMBL9128639;4-[(pyridin-4-yl)methyl]phenol;FQNZRIMTMGOVMD-UHFFFAOYSA-N;DTXSID901309860;AKOS020791597;FT-0765501;EN300-1074285;Z1513816031

Suppliers and Price of 4-(Pyridin-4-ylmethyl)phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 4-(Pyridin-4-ylmethyl)phenol

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:185.084063974
Heavy Atom Count:14
Complexity:158

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1CC2=CC=NC=C2)O

Technology Process of 4-(Pyridin-4-ylmethyl)phenol

There total 6 articles about 4-(Pyridin-4-ylmethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 108-89-4
picoline

: 106-41-2
4-bromo-phenol

: 66414-18-4
4-(pyridin-4-ylmethyl)phenol

Guidance literature:: picoline; With zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex; In tetrahydrofuran; at 25 ℃; for 1h; Inert atmosphere;

4-bromo-phenol; With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium(II) trifluoroacetate; In tetrahydrofuran; at 50 ℃; for 1h; Inert atmosphere;
DOI:10.1002/anie.201103074

Reference yield: 72.0%

: 35854-35-4
4-[(4-methoxyphenyl)methyl]pyridine

: 66414-18-4
4-(pyridin-4-ylmethyl)phenol

Guidance literature:: With hydrogen bromide; In acetic acid; for 6h; Heating;
DOI:10.1021/jm00174a007

Reference yield:

: 872-85-5
pyridine-4-carbaldehyde

: 66414-18-4
4-(pyridin-4-ylmethyl)phenol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) magnesium / 1.) THF, reflux, 2 h, 2.) reflux, 16 h

2: 86 percent / zinc, formic acid / 16 h / Heating

3: 72 percent / 48percent HBr / acetic acid / 6 h / Heating

With formic acid; hydrogen bromide; magnesium; zinc; In acetic acid;
DOI:10.1021/jm00174a007