6-Benzothiazolecarboxylic acid, 2-(2-hydroxyphenyl)-

Base Information

• Chemical Name: 6-Benzothiazolecarboxylic acid, 2-(2-hydroxyphenyl)-
• CAS No.: 664324-19-0
• Molecular Formula: C14H9NO3S
• Molecular Weight: 271.296
• Mol file: 664324-19-0.mol

Synonyms:

Chemical Property of 6-Benzothiazolecarboxylic acid, 2-(2-hydroxyphenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Benzothiazolecarboxylic acid, 2-(2-hydroxyphenyl)-

There total 7 articles about 6-Benzothiazolecarboxylic acid, 2-(2-hydroxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

salicylaldehyde (90-02-8) + 4-amino-3-mercaptobenzoic acid hydrochloride (1571-66-0) → 2-(2-hydroxyphenyl)benzo[d]thiazole-6-carboxylic acid (664324-19-0)

Guidance literature:

With sodium dithionite; In ethanol; water; for 36h; Reflux;

DOI:10.1016/j.bioorg.2020.103960

Reference yield:

C20H24N2OSSi (1411685-52-3) → 2-(2-hydroxyphenyl)benzo[d]thiazole-6-carboxylic acid (664324-19-0)

Guidance literature:

C₂₀H₂₄N₂OSSi; With sodium hydroxide; potassium hexacyanoferrate(III); In water; at 80 - 90 ℃; for 3h;

With hydrogenchloride; In water; at 20 ℃;

DOI:10.1039/c2jm34599d

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → 2-(2-hydroxyphenyl)benzo[d]thiazole-6-carboxylic acid (664324-19-0)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine / methanol / -5 °C

2: potassium hydroxide / Reflux

3: sodium dithionite / ethanol; water / 36 h / Reflux

With sodium dithionite; bromine; potassium hydroxide; In methanol; ethanol; water;

DOI:10.1016/j.bioorg.2020.103960

upstream raw materials:

4-Aminobenzonitrile

N-(4-cyanophenyl)-2-hydroxybenzamide

C₂₀H₂₄N₂OSSi

salicylic acid

Downstream raw materials:

C₁₆H₁₃NO₃S