Methyl 1-(tert-butoxycarbonylaMino)cyclopropanecarboxylate

Base Information

• Chemical Name: Methyl 1-(tert-butoxycarbonylaMino)cyclopropanecarboxylate
• CAS No.: 66494-26-6
• Molecular Formula: C10H17NO4
• Molecular Weight: 215.249
• Mol file: 66494-26-6.mol

Synonyms:methyl 1-(tert-butoxycarbonylamino)cyclopropanecarboxylate;1-(Boc-amino)-cyclopropanecarboxylic acid methyl ester;

Chemical Property of Methyl 1-(tert-butoxycarbonylaMino)cyclopropanecarboxylate

Chemical Property:

• Boiling Point: 290.5±19.0 °C(Predicted)
• PKA: 10.79±0.20(Predicted)
• PSA: 68.12000
• Density: 1.12±0.1 g/cm3(Predicted)
• LogP: 1.42110
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

Methyl1-(Boc-amino)-cyclopropanecarboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 1-(tert-butoxycarbonylaMino)cyclopropanecarboxylate

There total 9 articles about Methyl 1-(tert-butoxycarbonylaMino)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 1-<(tert-butyloxy)carbonylamino>cyclopropane-1-carboxylic acid (88950-64-5) → methyl 1-[[(tert-butoxy)carbonyl]amino]cyclopropane-1-carboxylate (66494-26-6)

Guidance literature:

In diethyl ether; dichloromethane; for 0.5h;

DOI:10.1002/1099-0690(200009)2000:18<3235::aid-ejoc3235>3.0.co;2-7

Reference yield: 99.0%

di-tert-butyl dicarbonate (24424-99-5) + methyl 1-aminocyclopropane-1-carboxylate hydrochloride (72784-42-0) → methyl 1-[[(tert-butoxy)carbonyl]amino]cyclopropane-1-carboxylate (66494-26-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 16h;

Reference yield: 97.0%

1-<(tert-butyloxy)carbonylamino>cyclopropane-1-carboxylic acid (88950-64-5) + diazomethyl-trimethyl-silane (18107-18-1) → methyl 1-[[(tert-butoxy)carbonyl]amino]cyclopropane-1-carboxylate (66494-26-6)

Guidance literature:

In methanol; toluene; at 20 ℃; for 0.5h;

DOI:10.1002/anie.201505898

upstream raw materials:

diazomethane

1-<(tert-butyloxy)carbonylamino>cyclopropane-1-carboxylic acid

di-tert-butyl dicarbonate

tert-butyl (1-(hydroxymethyl)cyclopropyl)carbamate

Downstream raw materials:

1-<(tert-butyloxy)carbonylamino>cyclopropane-1-carboxylic acid

tert-butyl [1-(3,5-dichlorophenylaminomethyl)cyclopropyl]carbamate

tert-butyl (1-((3,5-dichlorophenyl)carbamoyl)cyclopropyl)carbamate

tert-butyl (1-(hydroxymethyl)cyclopropyl)carbamate

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