2,2-dimethoxyethylsulfanylmethylbenzene

Base Information

• Chemical Name: 2,2-dimethoxyethylsulfanylmethylbenzene
• CAS No.: 6304-94-5
• Molecular Formula: C11H16 O2 S
• Molecular Weight: 212.313
• Hs Code.: 2930909090
• Mol file: 6304-94-5.mol

Synonyms:NSC 43153;[[(2,2-dimethoxyethyl)thio]methyl]benzene

Chemical Property of 2,2-dimethoxyethylsulfanylmethylbenzene

Chemical Property:

• Vapor Pressure: 0.00405mmHg at 25°C
• Boiling Point: 288.5°C at 760 mmHg
• Flash Point: 128.3°C
• PSA: 43.76000
• Density: 1.067g/cm³
• LogP: 2.53870

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-dimethoxyethylsulfanylmethylbenzene

There total 3 articles about 2,2-dimethoxyethylsulfanylmethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

chloroacetaldehyde dimethyl acetal (97-97-2) + phenylmethanethiol (100-53-8) → benzylmercaptoacetaldehyde dimethyl acetal (6304-94-5)

Guidance literature:

phenylmethanethiol; With sodium hydride; In tetrahydrofuran; for 2h; Heating;

chloroacetaldehyde dimethyl acetal; In tetrahydrofuran; for 48h; Heating;

DOI:10.1002/jccs.199900083

Reference yield: 98.0%

1-bromo-2,2-dimethoxyethane (7252-83-7) + phenylmethanethiol (100-53-8) → benzylmercaptoacetaldehyde dimethyl acetal (6304-94-5)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1055/s-0032-1317860

Reference yield:

chloroacetaldehyde dimethyl acetal (97-97-2) + sodium benzylmercaptide (3492-64-6) → benzylmercaptoacetaldehyde dimethyl acetal (6304-94-5)

Guidance literature:

With potassium iodide;

DOI:10.1021/ja01105a013

upstream raw materials:

chloroacetaldehyde dimethyl acetal

sodium benzylmercaptide

1-bromo-2,2-dimethoxyethane

phenylmethanethiol

Downstream raw materials:

dibenzyl disulphide

1,2-bis-(benzylmercapto)ethylene

2-amino-3-(benzylthio)propionic acid

benzylsulfanyl-acetaldehyde-semicarbazone

Refernces

• 1、 Wünsch, Matthias,Schr?der, David,Fr?hr, Tanja,Teichmann, Lisa,Hedwig, Sebastian,Janson, Nils,Belu, Clara,Simon, Jasmin,Heidemeyer, Shari,Holtkamp, Philipp,Rudlof, Jens,Klemme, Lennard,Hinzmann, Alessa,Neumann, Beate,Stammler, Hans-Georg,Sewald, Norbert. "Asymmetric synthesis of propargylamines as amino acid surrogates in peptidomimetics". supporting information. p. 2428 - 2441. Retrieved 2017/12/06.
• 2、 Sugimura, Hideyuki,Kusakabe, Kousuke. "Synthesis of 2-thioaldoses via BF3-promoted cycloaddition of β-methoxyvinyl sulfides with 2,3-O-isopropylidene derivatives of aldehydo-aldoses". . p. 69 - 72. Retrieved 2013/02/23.