5-Bromo-2-methoxythioanisole

Base Information

• Chemical Name: 5-Bromo-2-methoxythioanisole
• CAS No.: 66623-79-8
• Molecular Formula: C8H9BrOS
• Molecular Weight: 233.129
• Mol file: 66623-79-8.mol

Synonyms:

Chemical Property of 5-Bromo-2-methoxythioanisole

Chemical Property:

• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-2-methoxythioanisole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-2-methoxythioanisole

There total 6 articles about 5-Bromo-2-methoxythioanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

Dimethyldisulphide (624-92-0) + 2,4-dibromoanisole (21702-84-1) → (5-bromo-2-methoxyphenyl)(methyl)sulfane (66623-79-8)

Guidance literature:

With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 1.5h; Inert atmosphere;

Reference yield: 50.0%

5-bromo-2-methoxybenzenesulfonyl chloride (23095-05-8) + carbonic acid dimethyl ester (616-38-6) → (5-bromo-2-methoxyphenyl)(methyl)sulfane (66623-79-8)

Guidance literature:

With tin; water; potassium hydrogencarbonate; triphenylphosphine; sodium iodide; at 120 ℃; for 48h; Sealed tube;

DOI:10.1002/ejoc.202101037

Reference yield: 35.0%

1-bromo-4-methoxy-benzene (104-92-7) + methylsulfanylium (20828-73-3) → (5-bromo-2-methoxyphenyl)(methyl)sulfane (66623-79-8)

Guidance literature:

With tetrabutylammonium tetrafluoroborate; In dichloromethane;

DOI:10.1016/S0040-4039(98)00871-5

upstream raw materials:

1-bromo-4-methoxy-benzene

methylsulfanylium

1-methoxy-2-(methylsulfanyl)benzene

Dimethyldisulphide