Technology Process of 2,4-Heptadienoic acid,
7-[3-[(4R,6R)-6-[(1E,3E,8R)-8-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1,3
-nonadienyl]-2,2-dimethyl-1,3-dioxan-4-yl]phenyl]-7-(1-methoxy-1-methyl
ethoxy)-, ethyl ester, (2Z,4E,7S)-
There total 24 articles about 2,4-Heptadienoic acid,
7-[3-[(4R,6R)-6-[(1E,3E,8R)-8-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1,3
-nonadienyl]-2,2-dimethyl-1,3-dioxan-4-yl]phenyl]-7-(1-methoxy-1-methyl
ethoxy)-, ethyl ester, (2Z,4E,7S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: bis(triphenylphosphine)palladium(II) chloride; tri-n-butyltin hydride / benzene / 0.5 h / 20 °C
1.2: 58 percent / copper(I) 2-thiophenecarboxylate / various solvent(s) / 0 °C
2.1: 92 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 1 h / 0 °C
3.1: 82 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 1 h / 0 °C
With
bis(triphenylphosphine)palladium(II)-chloride; tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; pyridinium p-toluenesulfonate;
In
tetrahydrofuran; dichloromethane; benzene;
DOI:10.1016/j.tet.2005.01.062
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium; cyanogen bromide / tetrahydrofuran; hexane / -78 - -40 °C
2.1: bis(triphenylphosphine)palladium(II) chloride; tri-n-butyltin hydride / benzene / 0.5 h / 20 °C
2.2: 58 percent / copper(I) 2-thiophenecarboxylate / various solvent(s) / 0 °C
3.1: 92 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 1 h / 0 °C
4.1: 82 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 1 h / 0 °C
With
n-butyllithium; bis(triphenylphosphine)palladium(II)-chloride; bromocyane; tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; pyridinium p-toluenesulfonate;
In
tetrahydrofuran; hexane; dichloromethane; benzene;
DOI:10.1016/j.tet.2005.01.062
