1-Piperidinecarboxamide, N-[(2S)-2-[2-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-5 -(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrol-4-yl]propyl]-4-(4-pyridinyl)-

Base Information

Chemical Name:1-Piperidinecarboxamide, N-[(2S)-2-[2-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-5 -(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrol-4-yl]propyl]-4-(4-pyridinyl)-
CAS No.:667940-58-1
Molecular Formula:C38H47N5O2S
Molecular Weight:637.889
Hs Code.:

1-Piperidinecarboxamide,
N-[(2S)-2-[2-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-5
-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrol-4-yl]propyl]-4-(4-pyridinyl)-

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Chemical Property of 1-Piperidinecarboxamide, N-[(2S)-2-[2-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-5 -(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrol-4-yl]propyl]-4-(4-pyridinyl)-

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Technology Process of 1-Piperidinecarboxamide, N-[(2S)-2-[2-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-5 -(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrol-4-yl]propyl]-4-(4-pyridinyl)-

There total 6 articles about 1-Piperidinecarboxamide, N-[(2S)-2-[2-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-5 -(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrol-4-yl]propyl]-4-(4-pyridinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 581-45-3
4-(piperidin-4-yl)pyridine

: 1000819-37-3
C₃₄H₃₈N₄O₅S

: 667940-58-1
2-(1,1-dimethyl-2-oxo-2-(7-azabicyclo[2.2.1]heptan-7-yl)ethyl)-4-[(1S)-1-methyl-2-(4-{pyridin-4-yl}piperidin-1-yl)carbonylamino-ethyl]-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrole

Guidance literature:: for 2.5h;
DOI:10.1016/j.bmcl.2007.09.099

Reference yield: 36.0%

: 667940-67-2
C₂₇H₃₅N₃OS

: 581-45-3
4-(piperidin-4-yl)pyridine

: 7693-46-1
4-Nitrophenyl chloroformate

: 667940-58-1
2-(1,1-dimethyl-2-oxo-2-(7-azabicyclo[2.2.1]heptan-7-yl)ethyl)-4-[(1S)-1-methyl-2-(4-{pyridin-4-yl}piperidin-1-yl)carbonylamino-ethyl]-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrole

Guidance literature:: C₂₇H₃₅N₃OS; 4-Nitrophenyl chloroformate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.5h;

4-(piperidin-4-yl)pyridine; In dichloromethane; for 16h;

Reference yield:

: 666852-63-7
ethyl 2-methyl-2-(2-thienyl)propanoate

: 667940-58-1
2-(1,1-dimethyl-2-oxo-2-(7-azabicyclo[2.2.1]heptan-7-yl)ethyl)-4-[(1S)-1-methyl-2-(4-{pyridin-4-yl}piperidin-1-yl)carbonylamino-ethyl]-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrole

Guidance literature:: Multi-step reaction with 9 steps

1.1: nitronium tetrafluoborate / 1,2-dimethoxyethane / 4 h / -55 - -10 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol; ethyl acetate / 5 h / 1140.08 Torr

3.1: tetrahydrofuran / 16 h / Heating / reflux

4.1: sodium hydroxide; water / ethanol / 1.5 h / Heating / reflux

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h

5.2: 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h

6.2: 5 - 20 °C

7.1: hydrogenchloride / 1,4-dioxane; iso-butanol / 1 h / 90 °C

8.1: hydrazine / ethanol / 16 h / 20 °C

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C

9.2: 16 h

With hydrogenchloride; dmap; sodium hydroxide; nitronium tetrafluoborate; water; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; hydrazine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; iso-butanol;