4-BROMO-2-(PIPERAZIN-1-YL)THIAZOLE

Base Information

• Chemical Name: 4-BROMO-2-(PIPERAZIN-1-YL)THIAZOLE
• CAS No.: 668484-59-1
• Molecular Formula: C₇H₁₀BrN₃S
• Molecular Weight: 248.146
• Hs Code.: 2934100090
• Mol file: 668484-59-1.mol

Synonyms:1-(4-bromothiazol-2-yl)piperazine;4-bromo-2-(piperazin-1-yl)thiazole;

Chemical Property of 4-BROMO-2-(PIPERAZIN-1-YL)THIAZOLE

Chemical Property:

• PSA: 56.40000
• LogP: 1.70900
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Bromo-2-(piperazin-1-yl)thiazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BROMO-2-(PIPERAZIN-1-YL)THIAZOLE

There total 1 articles about 4-BROMO-2-(PIPERAZIN-1-YL)THIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

piperazine (110-85-0) + 2,4-dibromo-1,3-thiazole (4175-77-3) → 4-bromo-2-(piperazin-1-yl)thiazole (668484-59-1)

Guidance literature:

With triethylamine; In 1,4-dioxane; at 100 ℃; for 1h; Microwave irradiation;

DOI:10.1021/jm200497t

Reference yield:

4-bromo-2-(piperazin-1-yl)thiazole (668484-59-1) + phenylpropyolic acid (637-44-5) → 4-(4-bromothiazol-2-yl)-1-(3-phenylpropiolyl)-piperazine

Guidance literature:

upstream raw materials:

piperazine

2,4-dibromo-1,3-thiazole

Refernces

• 1、 -. "ARYLTHIAZOLYL PIPERIDINES AND RELATED COMPOUNDS AS MODULATORS OF SURVIVAL MOTOR NEURON (SMN) PROTEIN PRODUCTION". Page/Page column 24. . Retrieved 2011/11/01.