2-[Bis(3,5-dimethylphenyl)phosphino]benzaldehyde

Base Information

• Chemical Name: 2-[Bis(3,5-dimethylphenyl)phosphino]benzaldehyde
• CAS No.: 669091-00-3
• Molecular Formula: C23H23OP
• Molecular Weight: 346.409
• Hs Code.: 2931900090
• Mol file: 669091-00-3.mol

Synonyms:2-[bis(3,5-dimethylphenyl)phosphino]benzaldehyde;2-(di-3,5-dimethylphenylphosphino)benzaldehyde;

Chemical Property of 2-[Bis(3,5-dimethylphenyl)phosphino]benzaldehyde

Chemical Property:

• Melting Point: 106-110℃
• PSA: 30.66000
• LogP: 4.49090
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Air Sensitive

Purity/Quality:

97% ^*data from raw suppliers

2-[Bis(3,5-dimethylphenyl)phosphino]benzaldehyde, min. 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Reactant for asymmetric hydrogenation

Technology Process of 2-[Bis(3,5-dimethylphenyl)phosphino]benzaldehyde

There total 4 articles about 2-[Bis(3,5-dimethylphenyl)phosphino]benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

acetone (67-64-1) + 2-(di-3,5-dimethylphenylphosphino)benzaldehyde ethylene acetal → 2-[bis(3,5-dimethylphenyl)phosphino]benzaldehyde (669091-00-3)

Guidance literature:

With water; toluene-4-sulfonic acid; Reflux;

DOI:10.1021/jo300548z

Reference yield:

2-(2-bromophenyl)-1,3-dioxolan (34824-58-3) → 2-[bis(3,5-dimethylphenyl)phosphino]benzaldehyde (669091-00-3)

Guidance literature:

Multi-step reaction with 2 steps

1: t-BuLi / diethyl ether; pentane / 5 h / -78 - 20 °C

2: 280 mg / aq. TsOH / acetone / 8 h / Heating

With tert.-butyl lithium; toluene-4-sulfonic acid; In diethyl ether; acetone; pentane;

DOI:10.1021/jo035675+

Reference yield:

2-(di-3,5-dimethylphenylphosphino)benzaldehyde ethylene acetal → 2-[bis(3,5-dimethylphenyl)phosphino]benzaldehyde (669091-00-3)

Guidance literature:

With toluene-4-sulfonic acid; In acetone; for 8h; Heating;

DOI:10.1021/jo035675+

upstream raw materials:

2-(2-bromophenyl)-1,3-dioxolan

bis-(3,5-dimethylphenyl)chlorophosphine

acetone

Downstream raw materials:

(2S,5S)-1-[2-(di-3,5-dimethylphenylphosphino)-benzylideneamino]-2,5-diphenylpyrrolidine

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