Boc-N-Me-Met-OH

Base Information

• Chemical Name: Boc-N-Me-Met-OH
• CAS No.: 66959-86-2
• Molecular Formula: C₁₁H₂₁NO₄S
• Molecular Weight: 263.358
• Mol file: 66959-86-2.mol

Synonyms:N-[(1,1-Dimethylethoxy)carbonyl]-N-methyl-L-methionine;N-α-t-Boc-(S)-α-methylmethionine;Nα -t-Butyloxycarbonyl-Nα -methyl-L-methionine;N-(tert-butoxycarbonyl)-N-methyl-L-methionine;

Chemical Property of Boc-N-Me-Met-OH

Chemical Property:

• PSA: 92.14000
• LogP: 2.05960

Purity/Quality:

HPLC>98% ^*data from raw suppliers

Boc-N-Me-Met-OH 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Boc-N-Me-Met-OH

There total 6 articles about Boc-N-Me-Met-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(4S)-N-tert-butyloxycarbonyl-4-(2-methylthioethyl)-1,3-oxazolidin-5-one (225386-53-8) → N-α-t-Boc-(S)-α-methylmethionine (66959-86-2,91292-55-6)

Guidance literature:

With chloro-trimethyl-silane; sodium cyanoborohydride; In acetonitrile; for 0.25h; Ambient temperature;

DOI:10.1246/cl.1999.299

Reference yield: 43.0%

Boc-N-MeMet(O)-OH (1393121-77-1) → N-α-t-Boc-(S)-α-methylmethionine (66959-86-2,91292-55-6)

Guidance literature:

With 1,4-dithio-erythritol; In water; at 20 - 55 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2012.06.056

Reference yield:

N-tert-butoxycarbonyl-L-methionine (2488-15-5) + methyl iodide (74-88-4) → N-α-t-Boc-(S)-α-methylmethionine (66959-86-2,91292-55-6)

Guidance literature:

With sodium chloride; In tetrahydrofuran; hexane; mineral oil;

upstream raw materials:

N-tert-butoxycarbonyl-L-methionine

methyl iodide

(4S)-N-tert-butyloxycarbonyl-4-(2-methylthioethyl)-1,3-oxazolidin-5-one

Boc-N-MeMet(O)-OH

Downstream raw materials:

Boc-N-MeMet-Sar-Sar-D-Phe-NH₂

{(S)-1-[((S)-1-Carbamoyl-3-methylsulfanyl-propyl)-methyl-carbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

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