3-Oxazolidinecarboxylic acid, 4-[[[(1Z,3S)-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-[[[(1S)-1-(methoxy carbonyl)-2-oxopropyl]amino]carbonyl]-1-butenyl]amino]carbonyl]-2,2,5- trimethyl-, 1,1-dimethylethyl ester, (4S,5R)-

Base Information

Chemical Name:3-Oxazolidinecarboxylic acid, 4-[[[(1Z,3S)-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-[[[(1S)-1-(methoxy carbonyl)-2-oxopropyl]amino]carbonyl]-1-butenyl]amino]carbonyl]-2,2,5- trimethyl-, 1,1-dimethylethyl ester, (4S,5R)-
CAS No.:670233-22-4
Molecular Formula:C38H53N3O9Si
Molecular Weight:723.939
Hs Code.:

3-Oxazolidinecarboxylic acid,
4-[[[(1Z,3S)-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-[[[(1S)-1-(methoxy
carbonyl)-2-oxopropyl]amino]carbonyl]-1-butenyl]amino]carbonyl]-2,2,5-
trimethyl-, 1,1-dimethylethyl ester, (4S,5R)-

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Suppliers and Price of 3-Oxazolidinecarboxylic acid, 4-[[[(1Z,3S)-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-[[[(1S)-1-(methoxy carbonyl)-2-oxopropyl]amino]carbonyl]-1-butenyl]amino]carbonyl]-2,2,5- trimethyl-, 1,1-dimethylethyl ester, (4S,5R)-

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Chemical Property of 3-Oxazolidinecarboxylic acid, 4-[[[(1Z,3S)-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-[[[(1S)-1-(methoxy carbonyl)-2-oxopropyl]amino]carbonyl]-1-butenyl]amino]carbonyl]-2,2,5- trimethyl-, 1,1-dimethylethyl ester, (4S,5R)-

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Technology Process of 3-Oxazolidinecarboxylic acid, 4-[[[(1Z,3S)-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-[[[(1S)-1-(methoxy carbonyl)-2-oxopropyl]amino]carbonyl]-1-butenyl]amino]carbonyl]-2,2,5- trimethyl-, 1,1-dimethylethyl ester, (4S,5R)-

There total 5 articles about 3-Oxazolidinecarboxylic acid, 4-[[[(1Z,3S)-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-[[[(1S)-1-(methoxy carbonyl)-2-oxopropyl]amino]carbonyl]-1-butenyl]amino]carbonyl]-2,2,5- trimethyl-, 1,1-dimethylethyl ester, (4S,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 670233-21-3
(4S,5R)-4-[(Z)-(S)-3-(tert-Butyl-diphenyl-silanyloxy)-1-((1S,2R)-2-hydroxy-1-methoxycarbonyl-propylcarbamoyl)-but-1-enylcarbamoyl]-2,2,5-trimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 670233-22-4
(4S,5R)-4-[(Z)-(S)-3-(tert-Butyl-diphenyl-silanyloxy)-1-((S)-1-methoxycarbonyl-2-oxo-propylcarbamoyl)-but-1-enylcarbamoyl]-2,2,5-trimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: With jones reagent; In acetone;
DOI:10.1246/cl.2004.72

Reference yield:

: 143364-85-6
(4S,5R)-3-(tert-butoxycarbonyl)-2,2,5-trimethyl-1,3-oxazolidine-4-carboxylic acid

: 670233-22-4
(4S,5R)-4-[(Z)-(S)-3-(tert-Butyl-diphenyl-silanyloxy)-1-((S)-1-methoxycarbonyl-2-oxo-propylcarbamoyl)-but-1-enylcarbamoyl]-2,2,5-trimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / DCC; HOBt / dimethylformamide

2: 80 percent / DBU / tetrahydrofuran

3: 100 percent / LiOH / dioxane; H₂O

4: 100 percent / BOP; iPr₂NEt

5: 74 percent / Jones reagent / acetone

With lithium hydroxide; jones reagent; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetone; 2: Hornor-Emmons reaction;
DOI:10.1246/cl.2004.72

Reference yield:

: 670233-18-8
(4S,5R)-4-{[(Diethoxy-phosphoryl)-methoxycarbonyl-methyl]-carbamoyl}-2,2,5-trimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 670233-22-4
(4S,5R)-4-[(Z)-(S)-3-(tert-Butyl-diphenyl-silanyloxy)-1-((S)-1-methoxycarbonyl-2-oxo-propylcarbamoyl)-but-1-enylcarbamoyl]-2,2,5-trimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / DBU / tetrahydrofuran

2: 100 percent / LiOH / dioxane; H₂O

3: 100 percent / BOP; iPr₂NEt

4: 74 percent / Jones reagent / acetone

With lithium hydroxide; jones reagent; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; water; acetone; 1: Hornor-Emmons reaction;
DOI:10.1246/cl.2004.72