4-Oxazolecarboxylic acid, 2-[(1Z,3S)-1-[[[(4S,5R)-3-[(1,1-dimethylethoxy)carbonyl]-2,2,5-trimethyl- 4-oxazolidinyl]carbonyl]amino]-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1- butenyl]-5-methyl-, methyl ester

Base Information

Chemical Name:4-Oxazolecarboxylic acid, 2-[(1Z,3S)-1-[[[(4S,5R)-3-[(1,1-dimethylethoxy)carbonyl]-2,2,5-trimethyl- 4-oxazolidinyl]carbonyl]amino]-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1- butenyl]-5-methyl-, methyl ester
CAS No.:670233-23-5
Molecular Formula:C38H51N3O8Si
Molecular Weight:705.924
Hs Code.:

4-Oxazolecarboxylic acid,
2-[(1Z,3S)-1-[[[(4S,5R)-3-[(1,1-dimethylethoxy)carbonyl]-2,2,5-trimethyl-
4-oxazolidinyl]carbonyl]amino]-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-
butenyl]-5-methyl-, methyl ester

Synonyms:

Suppliers and Price of 4-Oxazolecarboxylic acid, 2-[(1Z,3S)-1-[[[(4S,5R)-3-[(1,1-dimethylethoxy)carbonyl]-2,2,5-trimethyl- 4-oxazolidinyl]carbonyl]amino]-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1- butenyl]-5-methyl-, methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 4-Oxazolecarboxylic acid, 2-[(1Z,3S)-1-[[[(4S,5R)-3-[(1,1-dimethylethoxy)carbonyl]-2,2,5-trimethyl- 4-oxazolidinyl]carbonyl]amino]-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1- butenyl]-5-methyl-, methyl ester

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-Oxazolecarboxylic acid, 2-[(1Z,3S)-1-[[[(4S,5R)-3-[(1,1-dimethylethoxy)carbonyl]-2,2,5-trimethyl- 4-oxazolidinyl]carbonyl]amino]-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1- butenyl]-5-methyl-, methyl ester

There total 6 articles about 4-Oxazolecarboxylic acid, 2-[(1Z,3S)-1-[[[(4S,5R)-3-[(1,1-dimethylethoxy)carbonyl]-2,2,5-trimethyl- 4-oxazolidinyl]carbonyl]amino]-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1- butenyl]-5-methyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 670233-22-4
(4S,5R)-4-[(Z)-(S)-3-(tert-Butyl-diphenyl-silanyloxy)-1-((S)-1-methoxycarbonyl-2-oxo-propylcarbamoyl)-but-1-enylcarbamoyl]-2,2,5-trimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 670233-23-5
2-[(Z)-(S)-1-[((4S,5R)-3-tert-Butoxycarbonyl-2,2,5-trimethyl-oxazolidine-4-carbonyl)-amino]-3-(tert-butyl-diphenyl-silanyloxy)-but-1-enyl]-5-methyl-oxazole-4-carboxylic acid methyl ester

Guidance literature:: With iodine; triethylamine; triphenylphosphine; In chloroform;
DOI:10.1246/cl.2004.72

Reference yield:

: 143364-85-6
(4S,5R)-3-(tert-butoxycarbonyl)-2,2,5-trimethyl-1,3-oxazolidine-4-carboxylic acid

: 670233-23-5
2-[(Z)-(S)-1-[((4S,5R)-3-tert-Butoxycarbonyl-2,2,5-trimethyl-oxazolidine-4-carbonyl)-amino]-3-(tert-butyl-diphenyl-silanyloxy)-but-1-enyl]-5-methyl-oxazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / DCC; HOBt / dimethylformamide

2: 80 percent / DBU / tetrahydrofuran

3: 100 percent / LiOH / dioxane; H₂O

4: 100 percent / BOP; iPr₂NEt

5: 74 percent / Jones reagent / acetone

6: 88 percent / I₂; PPh₃; Et₃N / CHCl₃

With lithium hydroxide; jones reagent; iodine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; chloroform; water; N,N-dimethyl-formamide; acetone; 2: Hornor-Emmons reaction;
DOI:10.1246/cl.2004.72

Reference yield:

: 670233-18-8
(4S,5R)-4-{[(Diethoxy-phosphoryl)-methoxycarbonyl-methyl]-carbamoyl}-2,2,5-trimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 670233-23-5
2-[(Z)-(S)-1-[((4S,5R)-3-tert-Butoxycarbonyl-2,2,5-trimethyl-oxazolidine-4-carbonyl)-amino]-3-(tert-butyl-diphenyl-silanyloxy)-but-1-enyl]-5-methyl-oxazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / DBU / tetrahydrofuran

2: 100 percent / LiOH / dioxane; H₂O

3: 100 percent / BOP; iPr₂NEt

4: 74 percent / Jones reagent / acetone

5: 88 percent / I₂; PPh₃; Et₃N / CHCl₃

With lithium hydroxide; jones reagent; iodine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; chloroform; water; acetone; 1: Hornor-Emmons reaction;
DOI:10.1246/cl.2004.72