4-Oxazolecarboxylic acid, 2-[(1Z,3S)-1-[[[(4S,5R)-3-[(1,1-dimethylethoxy)carbonyl]-2,2,5-trimethyl- 4-oxazolidinyl]carbonyl]amino]-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1- butenyl]-5-methyl-

Base Information

Chemical Name:4-Oxazolecarboxylic acid, 2-[(1Z,3S)-1-[[[(4S,5R)-3-[(1,1-dimethylethoxy)carbonyl]-2,2,5-trimethyl- 4-oxazolidinyl]carbonyl]amino]-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1- butenyl]-5-methyl-
CAS No.:670233-24-6
Molecular Formula:C37H49N3O8Si
Molecular Weight:691.897
Hs Code.:

4-Oxazolecarboxylic acid,
2-[(1Z,3S)-1-[[[(4S,5R)-3-[(1,1-dimethylethoxy)carbonyl]-2,2,5-trimethyl-
4-oxazolidinyl]carbonyl]amino]-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-
butenyl]-5-methyl-

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Chemical Property of 4-Oxazolecarboxylic acid, 2-[(1Z,3S)-1-[[[(4S,5R)-3-[(1,1-dimethylethoxy)carbonyl]-2,2,5-trimethyl- 4-oxazolidinyl]carbonyl]amino]-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1- butenyl]-5-methyl-

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Technology Process of 4-Oxazolecarboxylic acid, 2-[(1Z,3S)-1-[[[(4S,5R)-3-[(1,1-dimethylethoxy)carbonyl]-2,2,5-trimethyl- 4-oxazolidinyl]carbonyl]amino]-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1- butenyl]-5-methyl-

There total 7 articles about 4-Oxazolecarboxylic acid, 2-[(1Z,3S)-1-[[[(4S,5R)-3-[(1,1-dimethylethoxy)carbonyl]-2,2,5-trimethyl- 4-oxazolidinyl]carbonyl]amino]-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1- butenyl]-5-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 670233-23-5
2-[(Z)-(S)-1-[((4S,5R)-3-tert-Butoxycarbonyl-2,2,5-trimethyl-oxazolidine-4-carbonyl)-amino]-3-(tert-butyl-diphenyl-silanyloxy)-but-1-enyl]-5-methyl-oxazole-4-carboxylic acid methyl ester

: 670233-24-6
2-[(Z)-(S)-1-[((4S,5R)-3-tert-Butoxycarbonyl-2,2,5-trimethyl-oxazolidine-4-carbonyl)-amino]-3-(tert-butyl-diphenyl-silanyloxy)-but-1-enyl]-5-methyl-oxazole-4-carboxylic acid

Guidance literature:: With lithium hydroxide; In 1,4-dioxane; water;
DOI:10.1246/cl.2004.72

Reference yield:

: 143364-85-6
(4S,5R)-3-(tert-butoxycarbonyl)-2,2,5-trimethyl-1,3-oxazolidine-4-carboxylic acid

: 670233-24-6
2-[(Z)-(S)-1-[((4S,5R)-3-tert-Butoxycarbonyl-2,2,5-trimethyl-oxazolidine-4-carbonyl)-amino]-3-(tert-butyl-diphenyl-silanyloxy)-but-1-enyl]-5-methyl-oxazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 91 percent / DCC; HOBt / dimethylformamide

2: 80 percent / DBU / tetrahydrofuran

3: 100 percent / LiOH / dioxane; H₂O

4: 100 percent / BOP; iPr₂NEt

5: 74 percent / Jones reagent / acetone

6: 88 percent / I₂; PPh₃; Et₃N / CHCl₃

7: 100 percent / LiOH / dioxane; H₂O

With lithium hydroxide; jones reagent; iodine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; chloroform; water; N,N-dimethyl-formamide; acetone; 2: Hornor-Emmons reaction;
DOI:10.1246/cl.2004.72

Reference yield:

: 670233-18-8
(4S,5R)-4-{[(Diethoxy-phosphoryl)-methoxycarbonyl-methyl]-carbamoyl}-2,2,5-trimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 670233-24-6
2-[(Z)-(S)-1-[((4S,5R)-3-tert-Butoxycarbonyl-2,2,5-trimethyl-oxazolidine-4-carbonyl)-amino]-3-(tert-butyl-diphenyl-silanyloxy)-but-1-enyl]-5-methyl-oxazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / DBU / tetrahydrofuran

2: 100 percent / LiOH / dioxane; H₂O

3: 100 percent / BOP; iPr₂NEt

4: 74 percent / Jones reagent / acetone

5: 88 percent / I₂; PPh₃; Et₃N / CHCl₃

6: 100 percent / LiOH / dioxane; H₂O

With lithium hydroxide; jones reagent; iodine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; chloroform; water; acetone; 1: Hornor-Emmons reaction;
DOI:10.1246/cl.2004.72