1-(3-Benzyl-2,4-dihydroxyphenyl)ethan-1-one

Base Information

• Chemical Name: 1-(3-Benzyl-2,4-dihydroxyphenyl)ethan-1-one
• CAS No.: 67088-16-8
• Molecular Formula: C15H14O3
• Molecular Weight: 242.274
• DSSTox Substance ID: DTXSID80496629
• Wikidata: Q82345613
• Mol file: 67088-16-8.mol

Synonyms:67088-16-8;1-(3-Benzyl-2,4-dihydroxyphenyl)ethan-1-one;SCHEMBL5519291;DTXSID80496629

Chemical Property of 1-(3-Benzyl-2,4-dihydroxyphenyl)ethan-1-one

Chemical Property:

• XLogP3: 3.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 242.094294304
• Heavy Atom Count: 18
• Complexity: 284

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=C(C(=C(C=C1)O)CC2=CC=CC=C2)O

Technology Process of 1-(3-Benzyl-2,4-dihydroxyphenyl)ethan-1-one

There total 11 articles about 1-(3-Benzyl-2,4-dihydroxyphenyl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-benzyl-2,4-dimethoxyacetophenone (118713-65-8) → 3-C-benzyl-2,4-dihydroxyacetophenone (67088-16-8)

Guidance literature:

With boron tribromide; In dichloromethane; 1) -50 deg C, 1 h, 2) rt, 2 h;

DOI:10.1021/jm00124a014

Reference yield:

1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone (29682-12-0) → 2',4'-dihydroxy-4-acetophenone (89-84-9) + 3-C-benzyl-2,4-dihydroxyacetophenone (67088-16-8) + 5-C-benzyl-2,4-dihydroxyacetophenone (93898-99-8)

Guidance literature:

In trifluoroacetic acid; for 70h; Ambient temperature;

Reference yield:

(2,6-dimethyloxy-4-methyl)phenyl (32565-76-7) → 3-C-benzyl-2,4-dihydroxyacetophenone (67088-16-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 43 percent / AlCl₃ / CH₂Cl₂ / 1) 0 deg C, 1 h, 2) rt, 0.5 h

2: 90 percent / BBr₃ / CH₂Cl₂ / 1) -50 deg C, 1 h, 2) rt, 2 h

With aluminium trichloride; boron tribromide; In dichloromethane;

DOI:10.1021/jm00124a014

upstream raw materials:

3-C-benzyl-4-benzyloxy-2-hydroxyacetophenone

2-(phenylmethyl)-1,3-dihydroxybenzene

acetonitrile

1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone

Downstream raw materials:

4-(4-Acetyl-2-benzyl-3-hydroxy-phenoxymethyl)-3-methoxy-benzoic acid

5'-C-benzyl-2'-hydroxy-3',4'-dibenzyloxychalcone

5'-C-benzyl-2'-hydroxy-3',4'-dimethoxydihydrochalcone

5'-C-benzyl-2',3',4'-trihydroxydihydrochalcone