32565-76-7

Upstream product

• 100-39-0 benzyl bromide 
• 151-10-0 1,3-Dimethoxybenzene 
• 23112-96-1 (2,6-dimethoxyphenyl)boronic acid 
• 67-56-1 methanol 
• 22381-56-2 2-benzylcyclohexane-1,3-dione 
• 882980-43-0 2-benzyloxy-1-methylpyridinium triflate 
• 100-52-7 benzaldehyde 
• 103-83-3 N,N'-dimethylbenzylamine 
• 260783-80-0 N,N,N--trimethyl--1--phenylmethanaminium trifluoromethanesulfonate 
• 100-51-6 benzyl alcohol 
• 100-44-7 benzyl chloride 
• 98-80-6 phenylboronic acid 

Downstream Products

• 118713-65-8 3-benzyl-2,4-dimethoxyacetophenone 
• 3769-40-2 2-(phenylmethyl)-1,3-dihydroxybenzene 
• 152610-08-7 2-(2-benzyl-3-hydroxyphenoxy)benzoic acid methyl ester 
• 1026189-26-3 2-{2-Benzyl-3-[3-(5-ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-phenoxy}-benzoic acid methyl ester 
• 152610-09-8 2-[2-(phenylmethyl)-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-(phenylmethoxy)phenoxy]propoxy]-phenoxy]benzoic acid methyl ester 
• 67088-16-8 3-C-benzyl-2,4-dihydroxyacetophenone 
• 118683-04-8 4-(4-Acetyl-2-benzyl-3-hydroxy-phenoxymethyl)-3-methoxy-benzoic acid 

Relevant academic research and scientific papers

Carbohydrate monophosphine, preparation method and uses thereof

The present invention provides carbohydrate monophosphine having a general formula Ia, Ib, IIa or IIb, and a preparation method thereof, wherein the carbohydrate monophosphine comprises a mixture of Ia and Ib having different phosphorus atom configurations or a mixture of IIa and IIb having different phosphorus atom configurations. The invention relates to a borane adduct, an oxide, a sulfide or aselenide of the carbohydrate monophosphine. The invention also provides a carbohydrate monophosphine coordinated palladium complex, and uses of a catalytic system consisting of the carbohydrate monophosphine and a palladium salt or a complex, or the carbohydrate monophosphine coordinated palladium complex in catalysis of organic reactions, particular in catalysis of coupling reactions for formingC-C, or C-N bonds by using (pseudo) aryl halides.

Total Synthesis of Avrainvilleol

The first total synthesis of the marine natural product avrainvilleol is reported. The total synthesis features the first application of the transition-metal-free coupling of a tosyl hydrazone and a boronic acid to the preparation of a complex natural product, and the first example of this coupling with a hindered diortho substituted hydrazone substrate.

SN1 reactions in supercritical carbon dioxide in the presence of alcohols: The role of preferential solvation

Ethanol (3b) inhibits SN1 reactions of alkyl halides 1 in supercritical carbon dioxide (scCO2) and gives no ethers as products. The unexpected behaviour of alcohols 3 in the reaction of alkyl halides 1 with 1,3-dimethoxybenzene (2) in scCO2 under different conditions is rationalised in terms of Br?nsted and Lewis acid-base equilibria of reagents, intermediates, additives and products in a singular solvent characterised by: (i) the strong quadrupole and Lewis acid character of carbon dioxide, which hinders SN2 paths by strongly solvating basic solutes; (ii) the weak Lewis base character of carbon dioxide, which prevents it from behaving as a proton sink; (iii) the compressible nature of scCO2, which enhances the impact of preferential solvation on carbon dioxide availability for the solvent-demanding rate determining step.

Nickel-catalyzed cross couplings of benzylic ammonium salts and boronic acids: Stereospecific formation of diarylethanes via C-N bond activation

We have developed a nickel-catalyzed cross coupling of benzylic ammonium triflates with aryl boronic acids to afford diarylmethanes and diarylethanes. This reaction proceeds under mild reaction conditions and with exceptional functional group tolerance. Further, it transforms branched benzylic ammonium salts to diarylethanes with excellent chirality transfer, offering a new strategy for the synthesis of highly enantioenriched diarylethanes from readily available chiral benzylic amines.

Supercritical carbon dioxide: A promoter of carbon-halogen bond heterolysis

Amazing reaction medium: Supercritical carbon dioxide, with zero dipole moment, lower dielectric constant than pentane, and non-hydrogen-bonding behavior, ionizes carbon-halogen bonds, dissociates the resulting ion pairs, and escapes from capture by the carbocation intermediates at temperatures above 40 °C. These properties allow the observation of carbocation chemistry in the absence of acids.

Organocatalytic sequential one-pot double cascade asymmetric synthesis of Wieland-Miescher ketone analogues from a knoevenagel/hydrogenation/robinson annulation sequence: Scope and applications of organocatalytic biomimetic reductions

(Chemical Equation Presented) A practical and novel organocatalytic chemo- and enantioselective process for the cascade synthesis of highly substituted 2-alkyl-cyclohexane-1,3-diones and Wieland-Miescher (W-M) ketone analogs is presented via reductive alk

Thermally generated phenylcarbenium ions: acid-free and self-quenching Friedel-Crafts reactions

2-Benzyloxy-1-methylpyridinium triflate (1) serves as a stable precursor to a phenylcarbenium species as evidenced by its reactivity in Friedel-Crafts alkylations with electron-rich arenes.

Palladium catalyzed Suzuki-Miyaura coupling with aryl chlorides using a bulky phenanthryl N-heterocyclic carbene ligand

A novel bis-phenanthryl N-heterocyclic carbene (NHC) based palladium acetate catalyst was effective for the coupling of various aryl and vinyl chlorides with organoboron compounds. N,N-Bis-(2,9-dicyclohexyl-10-phenanthryl)- 4,5-dihydroimidazolium chloride 8 (H2ICP·HCl) with Pd(OAc)2 and KF·18-c-6 in THF at room temperature gave Suzuki-Miyaura coupling of aryl and vinyl chorides, including unactivated and di-ortho substituted substrates in high yields. Hindered tri- and tetra-ortho substituted products were also efficiently produced. Benzyl chloride was also found to be a useful coupling partner and trimethylboroxine was used to give methylated products. The effect of ligand, base, temperature, solvent, and reaction time are reported along with various substrates including halides and triflates.

Method for orthometalation of a carbocyclic aromatic derivative bearing at least an electron donor group

The invention concerns a method for orthometalation of a carbocyclic aromatic derivative bearing at least an electron donor group, characterised in that it consists in reacting said carbocyclic aromatic derivative with an efficient amount of at least one alkaline metal in the presence of a compound of formula (I): RX, wherein: R represents a hydrocarbon radical having 1 to 20 carbon atoms which can be a saturated or unsaturated, linear or branched, acyclic aliphatic radical; a saturated or unsaturated, monocyclic or polycyclic cycloaliphatic radical; a saturated or unsaturated, linear or branched aliphatic radical bearing a cyclic substituent; and X represents a bromine or chlorine atom.

Methods for identifying and treating resistant tumors

This invention provides a method of identifying and reversing multidrug resistance in a multidrug resistance tumor comprising administering a multidrug resistance reversing amount of any of the compounds as defined herein.