2-METHYLCYCLOPROPANEMETHANOL

Base Information

• Chemical Name: 2-METHYLCYCLOPROPANEMETHANOL
• CAS No.: 6077-72-1
• Molecular Formula: C5H10 O
• Molecular Weight: 86.1338
• Hs Code.: 2906199090
• Mol file: 6077-72-1.mol

Synonyms:(2-Methylcyclopropyl)methanol;(2-Methylcyclopropyl)methyl alcohol; 2-Methylcyclopropanemethanol

Chemical Property of 2-METHYLCYCLOPROPANEMETHANOL

Chemical Property:

• Vapor Pressure: 3.78mmHg at 25°C
• Refractive Index: n20/D 1.43(lit.)
• Boiling Point: 133 °C(lit.)
• PKA: 15.10±0.10(Predicted)
• Flash Point: 103 °F
• PSA: 20.23000
• Density: 0.87 g/mL at 25 °C(lit.)
• LogP: 0.63470
• Storage Temp.: Flammables area
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

(2-methylcyclopropyl)methanol ^*data from reagent suppliers

Safty Information:

• Statements: 10
• Safety Statements: 16

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: It is employed in the radical clock investigation of microsomal cytochrome P-450 hydroxylation of hydrocarbons.

Technology Process of 2-METHYLCYCLOPROPANEMETHANOL

There total 1 articles about 2-METHYLCYCLOPROPANEMETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

3-(3-Methyldiazirin-3-yl)propan-1-ol (16297-94-2) → n-Pent-4-enyl alcohol (821-09-0) + (3Z)-pent-3-en-1-ol (764-38-5) + (E)-3-penten-1-ol (764-37-4) + 2-methylcyclopropanemethanol (6077-72-1)

Guidance literature:

In 2,2,4-trimethylpentane; at 100 ℃; Kinetics; Product distribution; Mechanism; other temperatures (95-125 deg C); E_a (at 80 deg C);

DOI:10.1039/P29900000661

Reference yield: 94.0%

2-methylcyclopropanemethanol (6077-72-1) + 4-Nitrophenyl chloroformate (7693-46-1) → (2-methylcyclopropyl)methyl (4-nitrophenyl) carbonate

Guidance literature:

With pyridine; In dichloromethane; at 4 - 20 ℃; for 18h; Inert atmosphere;

DOI:10.3762/bjoc.15.54

Reference yield: 93.0%

3-hydroxy-5-[methyl(methylsulfonyl)amino]benzoic acid methyl ester (929041-90-7) + 2-methylcyclopropanemethanol (6077-72-1) → 3-[(2-methylcyclopropyl)methoxy]-5-[methyl(methylsulfonyl)amino]benzoic acid (695216-08-1)

Guidance literature:

3-hydroxy-5-[methyl(methylsulfonyl)amino]benzoic acid methyl ester; 2-methylcyclopropanemethanol; With dibenzyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 16.5h;

With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 15h;

With hydrogenchloride; In water; pH=3;

upstream raw materials:

3-(3-Methyldiazirin-3-yl)propan-1-ol

Downstream raw materials:

4-bromopent-1-ene

2-methyl-cyclopropanecarboxylic acid

2-methylcyclopropane carboxaldehyde

Benzoic acid (1S,2R)-2-methyl-cyclopropylmethyl ester

Refernces

• 1、 Stevens, Ian D. R.,Liu, Michael T. H.,Soundararajan, N.,Paike, N.. "THE BARRIER FOR 1,2 HYDROGEN SHIFT IN DIALKYL CARBENES". . p. 481 - 484. Retrieved 2007/10/02.