2-(5-phenyl-1,3,4-oxadiazol-2-yl)aniline

Base Information

• Chemical Name: 2-(5-phenyl-1,3,4-oxadiazol-2-yl)aniline
• CAS No.: 23047-95-2
• Molecular Formula: C14H11 N3 O
• Molecular Weight: 237.261
• Mol file: 23047-95-2.mol

Synonyms:1,3,4-Oxadiazole,2-(o-aminophenyl)-5-phenyl- (6CI,8CI); NSC 377831

Chemical Property of 2-(5-phenyl-1,3,4-oxadiazol-2-yl)aniline

Chemical Property:

• Vapor Pressure: 7E-08mmHg at 25°C
• Boiling Point: 438.3°Cat760mmHg
• Flash Point: 218.9°C
• Density: 1.238g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(5-phenyl-1,3,4-oxadiazol-2-yl)aniline

There total 22 articles about 2-(5-phenyl-1,3,4-oxadiazol-2-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

phenyl-2 (nitro-2 phenyl)-5 oxadiazole-1,3,4 (2518-61-8) → 2-(o-aminophenyl)-5-phenyl-1,3,4-oxadiazole (23047-95-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethanol; at 20 ℃; for 1h; under 2250.23 Torr;

DOI:10.1016/j.ejmech.2018.01.012

Reference yield: 77.0%

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) + benzoic acid hydrazide (613-94-5) → 2-(o-aminophenyl)-5-phenyl-1,3,4-oxadiazole (23047-95-2)

Guidance literature:

With potassium carbonate; potassium iodide; In dimethyl sulfoxide; at 120 ℃; for 2h; Reagent/catalyst; Solvent; Temperature; Electrolysis;

DOI:10.1021/acs.joc.0c01700

Reference yield: 70.0%

anthranilic acid hydrazide (1904-58-1) + orthobenzoic acid trimethyl ester (707-07-3) → 2-(o-aminophenyl)-5-phenyl-1,3,4-oxadiazole (23047-95-2)

Guidance literature:

In 1,4-dioxane; for 7h; Heating;

DOI:10.1002/jhet.5570210649

upstream raw materials:

phenyl-2 (nitro-2 phenyl)-5 oxadiazole-1,3,4

1-(2'-aminobenzoyl)-2-benzoylhydrazine

isatoic anhydride

benzoic acid hydrazide

Refernces

• 1、 K?hler, Sebastian C.,Vahdati, Sahel,Scholz, Matthias S.,Wiese, Michael. "Structure activity relationships, multidrug resistance reversal and selectivity of heteroarylphenyl ABCG2 inhibitors". . p. 483 - 500. Retrieved 2018/02/14.
• 2、 Diao, Pinhui,Ge, Yanqin,zhang, Wenpei,Xu, Chen,Zhang, Nannan,Guo, Cheng. "Synthesis of 2,5-disubstituted 1,3,4-oxadiazoles by visible-light-mediated decarboxylation–cyclization of hydrazides and diketones". supporting information. p. 767 - 770. Retrieved 2018/02/07.