5-BROMO-PYRIDINE-2-CARBOXYLIC ACID DIETHYLAMIDE

Base Information

• Chemical Name: 5-BROMO-PYRIDINE-2-CARBOXYLIC ACID DIETHYLAMIDE
• CAS No.: 673485-54-6
• Molecular Formula: C10H13BrN2O
• Molecular Weight: 257.13
• Hs Code.: 2933399090
• Mol file: 673485-54-6.mol

Synonyms:5-bromo-N,N-diethylpyridine-2-carboxamide;

Chemical Property of 5-BROMO-PYRIDINE-2-CARBOXYLIC ACID DIETHYLAMIDE

Chemical Property:

• Vapor Pressure: 2.6E-05mmHg at 25°C
• Boiling Point: 358.2oC at 760 mmHg
• Flash Point: 170.4oC
• PSA: 33.20000
• Density: 1.373g/cm3
• LogP: 2.32610
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-N,N-diethylpicolinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-PYRIDINE-2-CARBOXYLIC ACID DIETHYLAMIDE

There total 4 articles about 5-BROMO-PYRIDINE-2-CARBOXYLIC ACID DIETHYLAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

5-bromopyridine-2-carbonyl chloride (137178-88-2) + diethylamine (109-89-7) → 2-bromo-pyridine-2-carboxylic acid diethylamide (673485-54-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/adsc.201300895

Reference yield: 60.0%

2,5-dibromopyridine (624-28-2) + diethylaminoacetonitrile (3010-02-4) → 2-bromo-pyridine-2-carboxylic acid diethylamide (673485-54-6)

Guidance literature:

2,5-dibromopyridine; diethylaminoacetonitrile; With sodium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 10h;

With bis-trimethylsilanyl peroxide; In tetrahydrofuran; at 20 ℃; for 10h;

DOI:10.1021/jo030233j

Reference yield:

5-bromoisonicotinic acid (30766-11-1) → 2-bromo-pyridine-2-carboxylic acid diethylamide (673485-54-6)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 4 h / 20 - 40 °C

2: triethylamine / dichloromethane / 0 - 20 °C

With thionyl chloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/adsc.201300895

upstream raw materials:

2,5-dibromopyridine

diethylaminoacetonitrile

5-bromopyridine-2-carbonyl chloride

diethylamine

Downstream raw materials:

N,N-diethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinamide

C₁₇H₂₀N₂O₂

(E)-5-bromo-N,N-diethyl-3-(1-phenylbut-1-en-2-yl)picolinamide

(E)-3-(1,2-bis(4-methoxyphenyl)vinyl)-5-bromo-N,N-diethylpicolinamide

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