1-(3-(2-furanyl)propyl)-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine

Base Information

Chemical Name:1-(3-(2-furanyl)propyl)-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine
CAS No.:149710-89-4
Molecular Formula:C₂₀H₂₇NO₂
Molecular Weight:313.44
Hs Code.:
Mol file:149710-89-4.mol

Synonyms:Phenol,3-[1-[3-(2-furanyl)propyl]-3,4-dimethyl-4-piperidinyl]-, cis- (9CI); Phenol,3-[1-[3-(2-furanyl)propyl]-3,4-dimethyl-4-piperidinyl]-, cis-(?à)-

Suppliers and Price of 1-(3-(2-furanyl)propyl)-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1-(3-(2-furanyl)propyl)-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine

Chemical Property:

Vapor Pressure:9.61E-09mmHg at 25°C
Boiling Point:450.8°Cat760mmHg
Flash Point:226.4°C
PSA：36.61000
Density:1.058g/cm³
LogP:4.15540

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-(3-(2-furanyl)propyl)-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine

There total 7 articles about 1-(3-(2-furanyl)propyl)-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-Furan-2-yl-1-[(3R,4R)-4-(3-hydroxy-phenyl)-3,4-dimethyl-piperidin-1-yl]-propan-1-one

: 149710-89-4
(+/-)-1-<3-(2-furanyl)propyl>-3(R^*),4(R^*)-dimethyl-4-(3-hydroxyphenyl)piperidine

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; at 60 - 70 ℃; for 2h;
DOI:10.1021/jm00072a001

Reference yield:

: 73224-22-3
1-methyl-4-(3-methoxyphenyl)-1,2,3,6-tetrahydropyridine

: 149710-89-4
(+/-)-1-<3-(2-furanyl)propyl>-3(R^*),4(R^*)-dimethyl-4-(3-hydroxyphenyl)piperidine

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) n-BuLi / 1.) THF, 2.) THF

2: H₂SO₄

3: H₂ / 5percent Pt/C / ethanol

4: 1.) vinyl chloroformate, 2.) HCl, proton sponge / 2.) EtOH

5: 48percent aq. HBr, HOAc

6: Et₃N / dimethylformamide / 2 h / 90 °C

7: Red-Al / toluene / 2 h / 60 - 70 °C

With hydrogenchloride; n-butyllithium; Proton Sponge; Vinyl chloroformate; sulfuric acid; hydrogen bromide; hydrogen; acetic acid; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; platinum on activated charcoal; In ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00072a001

Reference yield:

: 149710-65-6
1,4,5,6-Tetrahydro-4-(3-methoxyphenyl)-N,N,1,4-tetramethyl-3-pyridinemethanamine

: 149710-89-4
(+/-)-1-<3-(2-furanyl)propyl>-3(R^*),4(R^*)-dimethyl-4-(3-hydroxyphenyl)piperidine

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / 5percent Pt/C / ethanol

2: 1.) vinyl chloroformate, 2.) HCl, proton sponge / 2.) EtOH

3: 48percent aq. HBr, HOAc

4: Et₃N / dimethylformamide / 2 h / 90 °C

5: Red-Al / toluene / 2 h / 60 - 70 °C

With hydrogenchloride; Proton Sponge; Vinyl chloroformate; hydrogen bromide; hydrogen; acetic acid; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; platinum on activated charcoal; In ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00072a001