1,4,5,6-Tetrahydro-4-(3-methoxyphenyl)-N,N,1,4-tetramethyl-3-pyridinemethanamine

Base Information

• Chemical Name: 1,4,5,6-Tetrahydro-4-(3-methoxyphenyl)-N,N,1,4-tetramethyl-3-pyridinemethanamine
• CAS No.: 149710-65-6
• Molecular Formula: C₁₇H₂₆N₂O
• Molecular Weight: 274.406

Synonyms:1,4,5,6-Tetrahydro-4-(3-methoxyphenyl)-N,N,1,4-tetramethyl-3-pyridinemethanamine

Chemical Property of 1,4,5,6-Tetrahydro-4-(3-methoxyphenyl)-N,N,1,4-tetramethyl-3-pyridinemethanamine

Chemical Property:

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Technology Process of 1,4,5,6-Tetrahydro-4-(3-methoxyphenyl)-N,N,1,4-tetramethyl-3-pyridinemethanamine

There total 3 articles about 1,4,5,6-Tetrahydro-4-(3-methoxyphenyl)-N,N,1,4-tetramethyl-3-pyridinemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 4-(3-Methoxy-phenyl)-1,4-dimethyl-1,2,3,4-tetrahydro-pyridine; compound with sulfuric acid + dimethyl amine (124-40-3) → 1,4,5,6-Tetrahydro-4-(3-methoxyphenyl)-N,N,1,4-tetramethyl-3-pyridinemethanamine (149710-65-6)

Guidance literature:

With sulfuric acid; In hexane; water; at 70 ℃; for 2h;

DOI:10.1021/jo00004a056

Reference yield:

1-methyl-4-(3-methoxyphenyl)-1,2,3,6-tetrahydropyridine (73224-22-3) → 1,4,5,6-Tetrahydro-4-(3-methoxyphenyl)-N,N,1,4-tetramethyl-3-pyridinemethanamine (149710-65-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, 2.) THF

2: H₂SO₄

With n-butyllithium; sulfuric acid;

DOI:10.1021/jm00072a001

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1,2,3,4-Tetrahydro-4-(3-methoxyphenyl)-1,4-dimethylpyridine (149710-64-5) + dimethyl amine (124-40-3) → 1,4,5,6-Tetrahydro-4-(3-methoxyphenyl)-N,N,1,4-tetramethyl-3-pyridinemethanamine (149710-65-6)

Guidance literature:

With sulfuric acid;

DOI:10.1021/jm00072a001

upstream raw materials:

formaldehyd

dimethyl amine

1,2,3,4-Tetrahydro-4-(3-methoxyphenyl)-1,4-dimethylpyridine

1-methyl-4-(3-methoxyphenyl)-1,2,3,6-tetrahydropyridine

Downstream raw materials:

4-(3-Methoxy-phenyl)-1,4,5-trimethyl-1,2,3,4-tetrahydro-pyridine

(3S,4R)-4-(3-Methoxy-phenyl)-1,3,4-trimethyl-piperidine

(+/-)-1,3(R^*),4(R^*)-Trimethyl-4-(3-methoxyphenyl)-piperidine

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