N-Hydroxy-2-toluidine

Base Information

Chemical Name:N-Hydroxy-2-toluidine
CAS No.:611-22-3
Molecular Formula:C7H9 N O
Molecular Weight:123.155
Hs Code.:
European Community (EC) Number:612-088-3
UNII:L90UBW6LOA
DSSTox Substance ID:DTXSID00209975
Nikkaji Number:J29.542F
Wikidata:Q26840953
Mol file:611-22-3.mol

Synonyms:N-hydroxy-2-toluidine;N-hydroxy-o-toluidine

Suppliers and Price of N-Hydroxy-2-toluidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of N-Hydroxy-2-toluidine

Chemical Property:

Vapor Pressure:0.0545mmHg at 25°C
Melting Point:44°C
Refractive Index:1.5380 (estimate)
Boiling Point:223.6°C at 760 mmHg
PKA:9.02±0.70(Predicted)
Flash Point:111°C
PSA：32.26000
Density:1.159g/cm³
LogP:1.86910
Storage Temp.:-20°C Freezer
Solubility.:Dichloromethane; Ethyl Acetate
XLogP3:1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:123.068413911
Heavy Atom Count:9
Complexity:85

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=CC=C1NO
Uses N-(o-Tolyl)hydroxylamine is an intermediate in the synthesis of Pyrametostrobin (P847010), a novel fungicide. Also, it is derived from 1-Methyl-2-nitrobenzene (N572306), which is a toxic pollutant of the environment because of its large scale use in the production of explosives. It is a useful synthetic intermediate. It shows carcinogenic activity in rats.

Technology Process of N-Hydroxy-2-toluidine

There total 22 articles about N-Hydroxy-2-toluidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 88-72-2
1-methyl-2-nitrobenzene

: 611-22-3
N-(o-tolyl)hydroxylamine

Guidance literature:: With hydrazine hydrate; In ethanol; water; 1,2-dichloro-ethane; at 45 ℃; for 2h; Temperature; Catalytic behavior;

Reference yield:

: 88-72-2
1-methyl-2-nitrobenzene

: 95-53-4
o-toluidine

: 611-22-3
N-(o-tolyl)hydroxylamine

Guidance literature:: In ethanol; water; at 25 ℃; Rate constant; Mechanism; Product distribution; polarographic reduction; potential-dependent rate constants k_f,h, αn_a; pH = 1.81-11.00;

Reference yield:

: 1143-74-4
N-o-tolylbenzohydroxamic acid

: 65-85-0,8013-63-6
benzoic acid

: 611-22-3
N-(o-tolyl)hydroxylamine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water; at 55 ℃; Further Variations:; Reagents; Kinetics;
DOI:10.1524/zpch.218.5.563.30505