Phosphinous acid, diphenyl-, 1,4-butanediyl ester

Base Information

• Chemical Name: Phosphinous acid, diphenyl-, 1,4-butanediyl ester
• CAS No.: 10274-30-3
• Molecular Formula: C28H28 O2 P2
• Molecular Weight: 458.4682
• NSC Number: 86050,77599
• UNII: HV2IDA1B0V
• DSSTox Substance ID: DTXSID00145480
• Nikkaji Number: J2.244.421B
• Wikidata: Q83010043
• Mol file: 10274-30-3.mol

Synonyms:10274-30-3;HV2IDA1B0V;Phosphinous acid, diphenyl-, 1,4-butanediyl ester;Tetramethylene diphenylphosphinate;NSC77599;UNII-HV2IDA1B0V;NSC 77599;NSC-77599;NSC-86050;4-diphenylphosphanyloxybutoxy(diphenyl)phosphane;DTXSID00145480;NSC86050;Bis(diphenylphosphinous acid)tetramethylene ester;PHOSPHINOUS ACID, DIPHENYL-, TETRAMETHYLENE ESTER

Chemical Property of Phosphinous acid, diphenyl-, 1,4-butanediyl ester

Chemical Property:

• Vapor Pressure: 1.64E-12mmHg at 25°C
• Boiling Point: 572.3°Cat760mmHg
• Flash Point: 376.8°C
• Density: g/cm³
• XLogP3: 6.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 11
• Exact Mass: 458.15645413
• Heavy Atom Count: 32
• Complexity: 398

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)P(C2=CC=CC=C2)OCCCCOP(C3=CC=CC=C3)C4=CC=CC=C4

Technology Process of Phosphinous acid, diphenyl-, 1,4-butanediyl ester

There total 3 articles about Phosphinous acid, diphenyl-, 1,4-butanediyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

Butane-1,4-diol (110-63-4) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → 1,4-butanediyl bis(diphenylphosphinite) (10274-30-3)

Guidance literature:

With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1246/cl.2005.1644

Reference yield:

succinic acid anhydride (108-30-5) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → 1,4-butanediyl bis(diphenylphosphinite) (10274-30-3)

Guidance literature:

With n; Yield given. Multistep reaction; 1) THF, rt; 2) THF, rt;

DOI:10.1021/jo951222w

Reference yield:

→ 1,4-butanediyl bis(diphenylphosphinite) (10274-30-3)

Guidance literature:

1,4-Butandiol, P-Chlor-diphenylphosphin, Ae., Zusatz von Diaethylanilin;

DOI:10.1021/jo01030a046

upstream raw materials:

Butane-1,4-diol

chloro-diphenylphosphine

succinic acid anhydride

Downstream raw materials:

1-((4-nitrophenyl)sulfonyl)pyrrolidine

Refernces

• 1、 Mukaiyama, Teruaki,Kuroda, Kiichi,Aoki, Hidenori. "A new method for the preparation of nitrogen-containing cyclic compounds from p-nitrobenzenesulfonamide and alkyl bis(diphenylphosphinite)s by oxidation-reduction condensation using 1-azidoadamantane". . p. 1644 - 1645. Retrieved 2007/10/03.
• 2、 Struck. "Synthesis of potential antineoplastic agents. 35. Phosphorus-containing structural analogs of myleran.". . p. 231 - 234. Retrieved 2007/10/05.